ONO-4059 - CAS 1351636-18-4
Catalog number:
1351636-18-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H22N6O3
Molecular Weight:
454.48
COA:
Inquire
Targets:
BTK
Description:
ONO-4059, a BTK inhibitor, has been found to have potential effect against sorts of malignancies by influencing the B-cell development. It is currently under Phase II trail to study its effect against Chronic lymphocytic leukaemia. IC50: 2.2 nM.
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Purity:
98%
Related CAS:
1439901-97-9 (HCl); 1351635-67-0 (ONO-4059-analog)
Appearance:
White to off white powder
Synonyms:
(R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one; ONO-4059; ONO4059; ONO 4059; ONO-4059; GS 4059; GS-4059; GS4059; ONO-WG-307; Tirabrutinib
Solubility:
Soluble in DMSO, not in water
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
ONO-4059 is a BTK inhibitor that has been found to have potential effect against sorts of malignancies by influencing the B-cell development.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
SEJLPXCPMNSRAM-GOSISDBHSA-N
InChI:
1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1
Canonical SMILES:
O=C1N(C2=CC=C(C=C2)OC3=CC=CC=C3)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5
Current Developer:
Gilead Sciences; Ono Pharmaceutical
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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