|Description||ONO-4059, a BTK inhibitor, has been found to have potential effect against sorts of malignancies by influencing the B-cell development. It is currently under Phase II trail to study its effect against Chronic lymphocytic leukaemia. IC50: 2.2 nM.|
|Related CAS||1439901-97-9 (HCl); 1351635-67-0 (ONO-4059-analog)|
|Appearance||White to off white powder|
|Synonyms||(R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one; ONO-4059; ONO4059; ONO 4059; ONO-4059; GS 4059; GS-4059; GS4059; ONO-WG-307; Tirabrutinib|
|Solubility||Soluble in DMSO, not in water|
|Application||ONO-4059 is a BTK inhibitor that has been found to have potential effect against sorts of malignancies by influencing the B-cell development.|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
|Current Developer||Gilead Sciences; Ono Pharmaceutical|
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Btk inhibitor 1 R enantiomer
Btk inhibitor 1 R enantiomer is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.