ONO-4057 - CAS 134578-96-4
Catalog number:
134578-96-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H34O7
Molecular Weight:
470.56
COA:
Inquire
Targets:
Leukotriene Receptor
Description:
ONO-4057 is a leukotriene B4 receptor antagonist originated by Ono Pharmaceutical. ONO-4057 is an Immunologic Factor and Immunosuppressive Agent. Clinical trials for the treatment of Behcet's syndrome, Gastritis and Ulcerative colitis was discontinued.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
Ono-LB-457; (E)-5-(2-(2-carboxyethyl)-3-((6-(4-methoxyphenyl)hex-5-en-1-yl)oxy)phenoxy)pentanoic acid
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Behcet's syndrome; Gastritis; Ulcerative colitis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
JOPSSWGWLCLPPF-RUDMXATFSA-N
InChI:
1S/C27H34O7/c1-32-22-15-13-21(14-16-22)9-4-2-3-6-19-33-24-10-8-11-25(23(24)17-18-27(30)31)34-20-7-5-12-26(28)29/h4,8-11,13-16H,2-3,5-7,12,17-20H2,1H3,(H,28,29)(H,30,31)/b9-4+
Canonical SMILES:
c1(CCC(=O)O)c(OCCCCC(=O)O)cccc1OCCCC\C=C\c1ccc(cc1)OC
Current Developer:
Originator Ono Pharmaceutical
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Leukotriene Receptor Products


iralukast
(CAS: 125617-94-9)

Iralukast is a Leukotriene D4 receptor antagonist originated by Novartis as a a structural analogue of LTD4. It is applicated for the treatment of asthma and in...

ZM-230487
(CAS: 155944-23-3)

ZM-230487, a quinolin derivative, has been found to be a 5-lipoxygenase inhibitor as well as Leukotriene D4 receptor antagonist. It was once studied in anti-inf...

CAS 117690-79-6 LY255283

LY255283
(CAS: 117690-79-6)

This active molecular is a competitive leukotriene B4 receptor antagonist and IC50 value is about 100 nM. LY 255283 is selective for the BLT2 receptor, since IC...

CP-85958
(CAS: 134002-60-1)

This active molecular is a selective LTD4 antagonist. CP-85958 may become a clinical candidates for the treatment of asthma in the future.

CAS 943764-99-6 Acebilustat

Acebilustat
(CAS: 943764-99-6)

Acebilustat, formerly known as ZK322, is an oral anti-inflammatory designed to reduce the production of leukotriene B4 (LTB4),.

LY 213024
(CAS: 117423-95-7)

LY 213024 is a potent leukotriene B4 receptor antagonist. Agents which block the production of the leukotrienes have shown reduction of infarct size in animal m...

LY 203647
(CAS: 122009-61-4)

LY 203647 is a a leukotriene D4 and E4 receptor antagonist with a tetrazole nucleus structure originated by Eli Lilly. No development for treatment of Ischaemic...

CAS 217799-03-6 KP496

KP496
(CAS: 217799-03-6)

KP496, a novel dual antagonist of cysLT receptor and TP, is currently in clinical development as a dry powder inhaler. KP496 inhibited epithelial hypertrophy an...

ONO-4057
(CAS: 134578-96-4)

ONO-4057 is a leukotriene B4 receptor antagonist originated by Ono Pharmaceutical. ONO-4057 is an Immunologic Factor and Immunosuppressive Agent. Clinical trial...

CAS 99107-52-5 U66858

U66858
(CAS: 99107-52-5)

U66858, also known as Bunaprolast, is a hydroquinone inhibitor of leukotriene synthesis, which inhibits LTB4 production in human whole blood.

Ono-RS-347
(CAS: 103176-67-6)

Ono-RS-347 is an SRS-A antagonist and a new leukotriene antagonists.

CP-195543
(CAS: 204981-48-6)

CP-195543 is a potent and selective leukotriene B4 antagonist developed as an oral treatment for for inflammatory diseases.

CAS 117423-74-2 LY223982

LY223982
(CAS: 117423-74-2)

This active molecular is benzophenone dicarboxylic acid derivative which is a potent BLT1 receptor antagonist. It inhibits the binding of radiolabeled-LTB4 to i...

CAS 148291-65-0 LY 210073

LY 210073
(CAS: 148291-65-0)

LY 210073, an oxoxanthene derivative, has been found to be a LTB4 receptor antagonist that could probably be effective against inflammation and rheumatic disord...

CAS 111130-13-3 Cgp-35949

Cgp-35949
(CAS: 111130-13-3)

Cgp-35949 is an LTD4 antagonist which has phospholipase inhibitory activity. It represents a new approach to the treatment of asthma.

CAS 154355-76-7 Atreleuton

Atreleuton
(CAS: 154355-76-7)

Atreleuton, a kind of urea compound, has been found to be a 5-lipoxygenase inhibitor as well as Leukotriene B4 receptor antagonist that could probably be useful...

CAS 128312-51-6 Cinalukast

Cinalukast
(CAS: 128312-51-6)

Cinalukast is a selective Leukotriene D4 receptor antagonist originated by Roche and IC 50 value is 6.4 nM. Cinalukast inhibits the actions of Leukotriene D4 at...

CAS 113806-05-6 Olopatadine

Olopatadine
(CAS: 113806-05-6)

This active molecular is an antihistamine, anticholinergic and mast cell stabilizer. Olopatadine blocks the action of endogenous histamine. It is used to treat ...

CAS 118414-82-7 MK-886

MK-886
(CAS: 118414-82-7)

This active molecular is a leukotriene antagonist with the IC50 of 3 nM in human polymorphonuclear leukocytes. MK-886 also inhibits PPARα activation. Inhibition...

CAS 712313-35-4 HAMI3379

HAMI3379
(CAS: 712313-35-4)

HAMI3379 is a cysteinyl leukotriene 2 (CysLT2) receptor antagonist. It can inhibit radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC5...

Quick Inquiry

Verification code

Featured Items