|Description||Ondansetron HCl is a serotonin 5-HT3 receptor antagonist.|
Sarizotan, also known as EMD-128130, is a full 5-HT1a agonist and a dopamine D2-like agonist/partial agonist used in clinical trials for the treatment of l-dopa...
Agomelatine L(+)-Tartaric acid
Agomelatine L(+)-Tartaric acid is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. It is used as an ant...
LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki...
Lu AE58054 is a selective and high affinity 5-HT6 receptor antagonist as promising treatment for cognitive disorders.
Tandospironeis a potent and selective 5-HT1A receptor partial agonist with Ki of 27 nM. It significantly reduces haloperidol-induced bradykinesia in a dose depe...
Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.
Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evalu...
Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.
GSK215083 is a PET radioligand for the 5-hydroxytrypamine-6 (5HT6) receptor. It is a quinoline based compounds that acts by antagonising the 5-HT6 receptor. It ...
BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.
The hydrochloride salt form of Alosetron which is an effective 5-HT3 receptor antagonist and could be commonly used against irritable bowel syndrome.
GYKI-46903 is a Muscarinic M3 receptor and Serotonin 3 receptor antagonist. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron bind...
BRL-15,572 is selective 5-HT1D antagonist with around 60x selectivity over other related receptors. It is a useful tool for the differentiation between human 5-...
The citrate salt form of tandospirone, a partial 5HT1A receptors agonist, could be effective as an antianxiety and antidepressant agent.
This active molecular is a Selective 5-HT6 Receptor antagonist, for the treatment of Alzheimer's Disease under development by by Avineuro Pharmaceuticals. AVN-2...
Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscar...
Granisetron HCl is a serotonin 5-HT3 receptor antagonist.
The hydrochloride salt form of Ramosetron, a benzimidazol derivative, could be used to against nausea and vomiting for acting as a 5-HT3 receptor antagonist.
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist for 5-HT ( IC50= 0.95 ± 0.12 nM ), and also exhibits agonist activity at dopamine ...
Velusetrag is a selective, 5-HT4receptor agonist. Phase II clinical trials for the treatment of gastroparesis are on-going. Clnical trials for Alzheimer's disea...