ON 146040 - CAS 1404231-34-0
Catalog number:
1404231-34-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H23N7O3S
Molecular Weight:
489.55
COA:
Inquire
Targets:
PI3K
Description:
ON 146040 was highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1,000 nM range. In biochemical testing, ON 146040 inhibited PI3K α/δ isoforms (IC50 ≈ 14 and 20 nM, respectively) without having a major effect on β/γ isoforms (IC50 ≈ 3 and 1 μM, respectively). ON 146040 was also found to inhibit Abl1 and several mutant versions of this kinase (IC50 < 150 nM), although the compound was not found to be active against the T315I mutant. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation were down-regulated in leukemia and myeloma cells.
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Purity:
>98%
Synonyms:
ON-146040; ON146040
MSDS:
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CAS 1404231-34-0 ON 146040

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