|Description||This active molecular is a DNA-directed DNA polymerase inhibitor potentially originated by Medivir AB. Omaciclovir can be selectively phosphorylated by viral thymidine kinase to its monophosphate form and it is further modified to a triphosphate, which is an inhibitor of VZV DNA polymerase. Preclinical trials for Herpes simplex virus infections, HIV infections and Varicella zoster virus infections were discontinued.|
|Synonyms||2-HMHBG; UNII-C9H909GLI3; Omaciclovir [USAN:INN]; C9H909GLI3; H 2G;2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-3H-purin-6-one|
|Solubility||Soluble in DMSO|
|Application||Herpes simplex virus infections, HIV infections and Varicella zoster virus infections|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator: Medivir AB|
MS-073 is a Type II DNA topoisomerase inhibitor under the development of Nihon Schering. MS-073 can overcome MDR in vitro and in vivo compare to verapamil. MS-0...
Datelliptium chloride, derived from ellipticine, is a DNA-intercalating agent with good activity in murine tumor models over a broad range of doses.
CP 115953 is a Type II DNA topoisomerase inhibitor originated by Pfizer. CP 115953 inhibits topoisomerase II activity via an interaction with the enzyme and not...
YU238259 is a novel inhibitor of homology-dependent DNA repair (HDR) while not inhibiting non-homologous end-joining in cell-based GFP reporter assays. Treatmen...
Caracemide is an agent derived from acetohydroxamic acid. It has potential antineoplastic activity. Caracemide can inhibit ribonuclease reductase, resulting in ...
BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-d...
The hydrochloride salt form of Tinostamustine, a benzimidazol derivative, has been found to be a HDAC inhibitor and could probably be effective against sorts of...
TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
GSK299423 is an antibiotic agent and it seems potentially effective in treating patients infected with bacteria expressing the New Delhi metallo-beta-lactamase....
TH588 hydrochloride, with potent anti-cancer property, is a novel inhibitor that highly selectively targets MTH1 protein (IC50= 5 nM) which is required for canc...
Oxolinic acid, a potent inhibitor of DNA gyrase and DNA synthesis, can examined Gyrase-chromosome interactions.
Amenamevir is a DNA helicase-primase inhibitors. It has anti-HSV activity against herpes simplex keratitis. In Mar 2016, Mahuro completed a phase III trial in H...
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 2...
Dezaguanine is a new antipurine antimetabolite. Dezaguanine is a DNA synthesis inhibitor. It has significant activity against transplantable rodent solid tumors...
This active molecular is a DNA-directed DNA polymerase inhibitor potentially originated by Medivir AB. Omaciclovir can be selectively phosphorylated by viral th...
LMI070, also called as NVS-SM1, is a selective, high plasma exposure and orally active modulator of SMN2 splicing which demonstrates robust activity across dise...
BRD7116, a bis-aryl sufone with cell-non-autonomous anti-leukemia activity, competitively binds to bacterial DNA gyrase and is an inhibitor of leukemia stem cel...
L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and ...
This active molecular is a topoisomerase I inhibitor originated by ShangHai HaiHe Pharmaceutical. Simmitecan is also a promising water-soluble prodrug of chimmi...
This active molecular has a Benzothiopyrano-indazole structure and the benzothiopyranoindazoles are potent inhibitors of nucleic acid synthesis, reducing both D...