Oltipraz - CAS 64224-21-1
Catalog number:
64224-21-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
HIF/HIF Prolyl-Hydroxylase
Description:
Oltipraz, a promising cancer chemopreventive agent, is a bifunctional inducer, modulating both phase I and II drug-metabolizing enzymes to enhance carcinogen detoxification.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Dark red solid
Synonyms:
CD1400
MSDS:
Inquire
1.Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells.
Edalat A1, Schulte-Mecklenbeck P, Bauer C, Undank S, Krippeit-Drews P, Drews G, Düfer M. Diabetologia. 2015 Jul;58(7):1532-41. doi: 10.1007/s00125-015-3577-9. Epub 2015 Apr 15.
AIMS/HYPOTHESIS: Generation of reduction equivalents is a prerequisite for nutrient-stimulated insulin secretion. Mitochondrial succinate dehydrogenase (SDH) fulfils a dual function with respect to mitochondrial energy supply: (1) the enzyme is part of mitochondrial respiratory chains; and (2) it catalyses oxidation of succinate to fumarate in the Krebs cycle. The aim of our study was to elucidate the significance of SDH for beta cell stimulus-secretion coupling (SSC).
2.Nuclear factor E2-related factor-2 (Nrf2) expression and regulation in male reproductive tract.
Wajda A1, Łapczuk J1, Grabowska M2, Słojewski M3, Laszczyńska M2, Urasińska E4, Droździk M5. Pharmacol Rep. 2016 Feb;68(1):101-8. doi: 10.1016/j.pharep.2015.07.005. Epub 2015 Jul 31.
BACKGROUND: Nuclear factor E2-related factor-2 (Nrf2, Nfe2l2) plays an important, protective role in many tissues. However, information on molecular mechanisms of detoxification and drug metabolism regulated by Nrf2/NRF2 in testis and epididymis is scarce, but it may help to better characterize the function of blood-testis and epididymis barriers.
3.The role of Nrf2 in pathology of pleomorphic adenoma in parotid gland.
Droździk A1, Kowalczyk R2, Jaworowska E3, Urasińska E4, Kurzawski M5. Med Sci Monit. 2015 Apr 30;21:1243-8. doi: 10.12659/MSM.892674.
BACKGROUND: Pleomorphic adenoma (benign mixed tumor) is one of the most common salivary gland tumors. However, the processes involved in its carcinogenesis are not well defined. This study aimed to define the contribution of Nfr2 (nuclear factor (erythroid-derived 2)-like 2) to pleomorphic adenoma pathology. The Nrf2-controlled gene system is one of the most critical cytoprotective mechanisms, providing antioxidant responses.
4.ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury.
Rao J1, Qian X, Li G, Pan X, Zhang C, Zhang F, Zhai Y, Wang X, Lu L. Am J Transplant. 2015 Jan;15(1):76-87. doi: 10.1111/ajt.12954. Epub 2014 Oct 30.
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that has been shown to repress inflammatory gene expression in multiple cell types and diseases. However, little is known about the roles and mechanisms of ATF3 in liver ischemia/reperfusion injury (IRI). In warm and cold liver IRI models, we showed that ATF3 deficiency significantly increased ischemia/reperfusion (IR)-stressed liver injury, as evidenced by increased serum alanine aminotransferase levels, histological liver damage, and hepatocellular apoptosis. These may correlate with inhibition of the intrahepatic nuclear factor erythroid-derived 2-related factor 2/heme oxygenase-1 (NRF2/HO-1) signaling pathway leading to enhancing Toll-like receptor 4/nuclear factor kappa beta (TLR4/NF-κB) activation, pro-inflammatory programs and macrophage/neutrophil trafficking, while simultaneously repressing anti-apoptotic molecules in ischemic liver. Interestingly, activation of NRF2/HO-1 signaling using an NRF2 activator, oltipraz (M2), during hepatic IRI-rescued ATF3 anti-inflammatory functions in ATF3-deficient mice.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related HIF/HIF Prolyl-Hydroxylase Products


DASA-58
(CAS: 1203494-49-8)

DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

CAS 931398-72-0 IOX2

IOX2
(CAS: 931398-72-0)

CAS 64224-21-1 Oltipraz

Oltipraz
(CAS: 64224-21-1)

Oltipraz, a promising cancer chemopreventive agent, is a bifunctional inducer, modulating both phase I and II drug-metabolizing enzymes to enhance carcinogen de...

CAS 327-97-9 Chlorogenic Acid

Chlorogenic Acid
(CAS: 327-97-9)

Chlorogenic acid is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.

PT-2385
(CAS: 1672665-49-4)

PT-2385 is a small molecule inhibitor with oral activity that inhibits hypoxia inducible factor (HIF)-2alpha heterodimerization and its subsequent binding to DN...

CAS 1187990-87-9 MK-8617

MK-8617
(CAS: 1187990-87-9)

MK-8617 is a potent and selective pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3) (PHD1: IC50 = 1.0 nM; PHD2: IC50 =1.0nM; PHD3: I...

CAS 1227158-85-1 BAY 87-2243

BAY 87-2243
(CAS: 1227158-85-1)

BAY 87-2243 inhibits HIF-1 reporter gene activity and CA9 protein expression with IC50 of 0.7 nM and 2 nM, respectively.

CAS 1154028-82-6 Molidustat

Molidustat
(CAS: 1154028-82-6)

Molidustat, also known as BAY 85-3934, is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) prod...

CAS 89464-63-1 DMOG

DMOG
(CAS: 89464-63-1)

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.

CAS 362-07-2 2-methoxyestradiol

2-methoxyestradiol
(CAS: 362-07-2)

2-methoxyestradiol, also known as 2-ME, is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angio...

KC7F2
(CAS: 927822-86-4)

KC7F2 is a selective HIF-1α transcription inhibitor with IC50 of 20 μM in a cell-based assay.

CAS 1357171-62-0 ML228

ML228
(CAS: 1357171-62-0)

HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of i...

CAS 808118-40-3 Roxadustat (FG-4592)

Roxadustat (FG-4592)
(CAS: 808118-40-3)

Roxadustat (FG-4592) is an HIF α prolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production.

THS-044
(CAS: 62054-67-5)

THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.

Daprodustat
(CAS: 960539-70-2)

Daprodustat, also known as GSK1278863, is a novel HIF-prolyl hydroxylase inhibitor. Hypoxia inducible factor (HIF) stabilization by HIF-prolyl hydroxylase (PHD)...

CAS 685898-44-6 PX-478

PX-478
(CAS: 685898-44-6)

PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be ...

FG-2216
(CAS: 223387-75-5)

FG-2216, also known as YM311, is orally bioavailable HIF-prolyl hydroxylase inhibitor. FG-2216 induced significant and reversible Epo induction in vivo.

JNJ-42041935
(CAS: 1193383-09-3)

JNJ-42041935 is a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. JNJ-42041935 is a new pharmacologica...

Chemical Structure

CAS 64224-21-1 Oltipraz

Quick Inquiry

Verification code

Featured Items