Olprinone - CAS 106730-54-5
Catalog number: 106730-54-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Phosphodiesterase (PDE)
Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.
Publictions citing BOC Sciences Products
  • >> More
1. Synthesis of imidazo[1,2-a]pyridines: a decade update
Avik Kumar Bagdi, Sougata Santra, Kamarul Monir and Alakananda Hajra*. Chem. Commun., 2015, 51, 1555—1575
Imidazopyridine, the imidazole moiety fused with the pyridine ring, is an important biologically active nitrogen containing heterocycle. Among the various imidazopyridine derivatives, the imidazo[1,2-a]pyridine moiety is the most important in the area of natural products and pharmaceuticals. These derivatives show a wide range of biological activities such as anti-fungal, antiinflammatory, antitumor, antiviral, antibacterial, antiprotozoal, antipyretic, analgesic, antiapoptotic, hypnoselective, and anxioselective activities. They also act as b-amyloid formation inhibitors, GABA and benzodiazepine receptor agonists, and cardiotonic agents. There are several drugs such as zolpidem (1, used in the treatment of insomnia), alpidem (2, as an anxiolytic agent),olprinone (3, for the treatment of acute heart failure), zolimidine (4, used for the treatment of peptic ulcer), necopidem and saripidem (5 and 6, both work as an anxiolytic agent) available in the market which contain the imidazo[1,2-a]pyridine moiety (Fig. 1). The optically active GSK812397 is a drug for the treatment of HIV infection. The antibiotic drug Rifaximin also contains this fused heterocyclic moiety.
2. Cu-Catalyzed selective C3-formylation of imidazo[1,2-a]pyridine C–H bonds with DMSO using molecular oxygen
Hua Cao,* Sai Lei, Naiying Li, Longbin Chen. Chem. Commun., 2015, 51, 1823—1825
Our recent efforts included the construction of imidazo[1,2-a]-pyridines by direct C–H functionalization or the multicomponent reaction. Imidazo[1,2-a]pyridine and its derivatives as important fine chemicals have been found to be key structural units in many natural products and drugs, such as zolpidem, alpidem, zolimidine, olprinone, saripidem, and necopidem, and exhibit a broad range of biological activities. There has been long-standing interest in the development of new and efficient transformation for the synthesis of imidazo[1,2-a]pyridines due to their great important applications. In continuation of our interest in preparing imidazo[1,2-a]pyridine derivatives by direct C–H functionalization, we reported a novel and facile copper-catalyzed C-3 formylation of imidazo[1,2-a]pyridines with DMSO utilizing molecular oxygen as the terminal oxidant.
3. Ruthenium-catalyzed direct C-3 oxidative olefination of imidazo[1,2-a]pyridines
Haiying Zhan, Limin Zhao,* Naiying Li, Longbin Chen, Jingyun Liu, Jinqiang Liao and Hua Cao*. RSC Adv.,2014, 4, 32013–32016
We are particularly interested in the development of new catalytic transformation that exploit selective C–H functionalization to elaborate simple imidazo[1,2-a]pyridines to useful products. Imidazo[1,2-a]pyridine rings are among the most important heterocyclic structural motifs. It has been found to be key structural units inmany pharmaceuticals and exhibited a wide range of biological activities, such as zolpidem, zolimidine, and alpidem, necopidem, olprinone, and divalpon. Thus, the development of short and facile routes for the construction of imidazo[1,2-a]pyridine compounds through transition-metal-catalyzed functionalizations has received intensive attention. Among thesemetal, Pd, Au, Ag, and Cu is the favorable catalysts for the preparation of imidazo[1,2-a]pyridine derivatives. transition-metal-catalyzed transformation has been developed for the synthesis of imidazo[1,2-a]pyridine derivatives during the last few years, there has only been a rare example for the direct oleflnation of imidazo[1,2-a]pyridine.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Phosphodiesterase (PDE) Products

CAS 862189-95-5 Mirodenafil

(CAS: 862189-95-5)

Mirodenafil is a newly developed oral phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. It significantly improved ...

CAS 192767-01-4 L791943

(CAS: 192767-01-4)

L791943 is a highly potent and metabolically stable PDE4 inhibitor with good in vitro activity (IC50= 4.2 nM). L-791, 943 is potent in vitro and in vivo as demo...

CAS 13460-98-5 Theodrenaline

(CAS: 13460-98-5)

Theodrenaline, also known as noradrenalinoethyltheophylline, is a cardiac stimulant with anti-hypotensive property together with cafedrine.

CAS 1904611-63-7 PDE1-IN-2

(CAS: 1904611-63-7)

PDE1-IN-2 is an inhibitor of PDE1 that has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely.

CAS 257892-33-4 AWD 12-281

AWD 12-281
(CAS: 257892-33-4)

AWD 12-281 is a strong selective phosphodiesterase 4 (PDE4) inhibitor which has potent effects in models of lung inflammation using inhalative administration.

CAS 224785-91-5 Vardenafil hydrochloride

Vardenafil hydrochloride
(CAS: 224785-91-5)

A phsphodiesterase 5 inhibitor.

CAS 152815-28-6 RS 25344 hydrochloride

RS 25344 hydrochloride
(CAS: 152815-28-6)

RS 25344 hydrochloride is a potent and selective inhibitor of four cloned isoforms of PDE4 (A, B, C and D) and phosphorylated PDE4D (IC50= 0.28, > 100, 160 and ...

CAS 898563-00-3 TP-10

(CAS: 898563-00-3)

TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. It has extremely potent PDE10A inhibitory activity and high selectivity against other PDEs. It is active in the...

CAS 1440898-61-2 Deltarasin

(CAS: 1440898-61-2)

Deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by Deltarasin suppresses proliferation of human pancr...

CAS 58337-38-5 EHNA hydrochloride

EHNA hydrochloride
(CAS: 58337-38-5)

EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM) and also an inhibitor of adenosine deaminase. EHNA i...

CAS 78033-08-6 MMPX

(CAS: 78033-08-6)

MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC50 = 5.2 μM). It causes an increase in cGMP but not cAMP, prolonging signal...

CAS 1144035-53-9 PF-8380

(CAS: 1144035-53-9)

PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 ...

CAS 1305116-67-9 PF 04671536 hydrochloride

PF 04671536 hydrochloride
(CAS: 1305116-67-9)

PF 04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A) (IC50= 1.3 and 1.9 nM, respectively), with s...

CK 3197
(CAS: 132523-92-3)

CK 3197 is a Phosphoric diester hydrolase inhibitor originated by Bayer HealthCare Pharmaceuticals. CK 3197 has hemodynamic and myocardial energetic effects. In...

CAS 139755-83-2 Sildenafil

(CAS: 139755-83-2)

An orally active selective type 5 cGMP phosphodiesterase inhibitor.

CAS 947620-48-6 RVT-501

(CAS: 947620-48-6)

RVT-501, also referred to E6005, is a selective phosphodiesterase 4 (PDE4) inhibitor (IC50= 2.8 nM) with potential effect to treat atopic dermatitis.

CAS 50847-11-5 Ibudilast

(CAS: 50847-11-5)

Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barri...

CAS 6493-05-6 Pentoxifylline

(CAS: 6493-05-6)

Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis,...

CAS 152633-54-0 Win-62005

(CAS: 152633-54-0)

Win-62005 competitively and selectively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta (Kis= 25 a...

CAS 77469-98-8 Pimobendan hydrochloride

Pimobendan hydrochloride
(CAS: 77469-98-8)

Pimobendan hydrochloride is a selective inhibitor of PDE3. It exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32...

Chemical Structure

CAS 106730-54-5 Olprinone

Quick Inquiry

Verification code

Featured Items