|Description||Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.|
Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic ag...
PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high se...
Denaverine hydrochloride is a phosphodiesterase inhibitor.Denaverine hydrochloride is applied in relaxation and delatation of birth canal in animals and spasms ...
Papaverine hydrochloride, an opium alkaloid antispasmodic, is a selective phosphodiesterase inhibitor used primarily in the treatment of visceral spasm, vasospa...
Pimobendan is both a calcium sensitizer and a selective inhibitor of phosphodiesterase III (PDE3) with positive inotropic and vasodilator effects.
L791943 is a highly potent and metabolically stable PDE4 inhibitor with good in vitro activity (IC50= 4.2 nM). L-791, 943 is potent in vitro and in vivo as demo...
BAY 73-6691 is a phosphodiesterase inhibitor selective for the PDE9A subtype under the development of Bayer. It selectively inhibits human PDE9 with IC50 value ...
JNJ-10258859 is a novel, potent, and selective phosphodiesterase type 5 inhibitor 5 with a K(i) of 0.23 nM and displayed excellent selectivity versus phosphodie...
RPL 554 is a potent and selective PDE3/4 inhibitor for respiratory diseases, particularly in patients with asthma.
Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 ...
FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It ...
Theodrenaline, also known as noradrenalinoethyltheophylline, is a cardiac stimulant with anti-hypotensive property together with cafedrine.
HA-130, an effective autotaxin (ATX) inhibitor, has been found to restrain the cell migration related to ATX in in an A2058 melanoma cells. IC50: 28 nM.
BRL 50481 is a potent, selective substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM).
(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor. It is 2.5-fold more potent than (+)-rolipram in inhibiting membrane-bound PDE 4.
AWD 12-281 is a strong selective phosphodiesterase 4 (PDE4) inhibitor which has potent effects in models of lung inflammation using inhalative administration.
Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
ITI214 is a highly selective PDE1 inhibitor (Ki = 58 pM) at picomolar concentration without disrupting other PDE family members and a panel of enzymes, receptor...
A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.
CI-1018 is a selective type 4 phosphodiesterase inhibitor associated with vasculitis. CI-1018 has been in development to suppress inflammation.