Olopatadine HCl - CAS 140462-76-6
Catalog number: 140462-76-6
Category: Inhibitor
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Molecular Formula:
C21H23NO3.HCl
Molecular Weight:
373.87
COA:
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Targets:
Histamine Receptor
Description:
Olopatadine HCl is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine
Purity:
>98%
Synonyms:
Olopatadine HCl; Olopatadine Hydrochloride; Pataday; Patanase; ALO-4943A; ALO 4943A; ALO4943A;
MSDS:
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InChIKey:
HVRLZEKDTUEKQH-NOILCQHBSA-N
InChI:
InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
Canonical SMILES:
CN(C)CCC=C1C2=CC=CC=C2COC3=C1C=C(C=C3)CC(=O)O.Cl
1.Efficacy of olopatadine versus epinastine for treating allergic conjunctivitis caused by Japanese cedar pollen: a double-blind randomized controlled trial.
Fukushima A1, Ebihara N. Adv Ther. 2014 Oct;31(10):1045-58. doi: 10.1007/s12325-014-0156-2. Epub 2014 Oct 1.
INTRODUCTION: The objective of this study was to compare the efficacy and safety of olopatadine versus epinastine in healthy Japanese adults with a history of allergic conjunctivitis to Japanese cedar pollen.
2.Alcaftadine for the prevention of itching associated with allergic conjunctivitis.
Mahvan TD1, Buckley WA, Hornecker JR. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1025-32. doi: 10.1345/aph.1Q755. Epub 2012 Jul 17.
OBJECTIVE: To evaluate the safety and efficacy of alcaftadine for the prevention of itching associated with allergic conjunctivitis.
3.Olopatadine hydrochloride suppresses hot flashes induced by topical treatment with tacrolimus ointment in rats.
Satake K1, Ikeda J2, Tamura T3, Amano T3, Kobayashi K3. Eur J Pharmacol. 2015 Oct 15;765:402-5. doi: 10.1016/j.ejphar.2015.09.008. Epub 2015 Sep 8.
Tacrolimus ointment is prescribed for patients with atopic dermatitis, although it is known to cause transient burning sensations and hot flashes in the applied skin. The aim of this study was to evaluate the effects of olopatadine hydrochloride (olopatadine), an antiallergic agent with a histamine H1 receptor (H1R) antagonistic activity, on the incidence of hot flashes induced by topical treatment with tacrolimus ointment in rats. Consequently, the skin temperature was increased by the topical application of tacrolimus ointment in rats, and the rise in skin temperature was inhibited by pretreatment with olopatadine in a dose-dependent manner. Inhibitory effect of olopatadine on tacrolimus-induced skin temperature elevation was significantly more potent than that of cetirizine hydrochloride, other antiallergic agent with H1R antagonistic activity, at doses in which both agents exhibit comparable H1R antagonistic activity in rats. These results suggest that H1R antagonistic activity-independent mechanism contribute to the inhibitory effect of olopatadine on tacrolimus-induced skin temperature elevation.
4.Ocular pharmacokinetics comparison between 0.2% olopatadine and 0.77% olopatadine hydrochloride ophthalmic solutions administered to male New Zealand white rabbits.
Iyer GR1, Cason MM, Womble SW, Li G, Chastain JE. J Ocul Pharmacol Ther. 2015 May;31(4):204-10. doi: 10.1089/jop.2014.0140. Epub 2015 Mar 16.
PURPOSE: The primary objective of this study was to compare uptake and distribution of the commercially available formulation of 0.2% olopatadine and the newly developed 0.77% olopatadine hydrochloride ophthalmic solution formulation with improved solubility following a single (30 μL), bilateral topical ocular dose in male New Zealand white rabbits.
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CAS 140462-76-6 Olopatadine HCl

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