Olcegepant hydrochloride - CAS 586368-06-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C38H47Br2N9O5.HCl
Molecular Weight:
906.11
COA:
Inquire
Targets:
CGRP Receptor
Description:
Olcegepant hydrochloride is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with 150-fold selective over the peptidic antagonist CGRP8-37 (IC50= 0.03 nM, Ki= 14.4 pM for human CGRP).
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Brife Description:
The first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) (IC50= 0.03 nM, Ki= 14.4 pM for human CGRP)
Synonyms:
N-[(2R)-1-[[(2S)-6-amino-1-oxo-1-(4-pyridin-4-ylpiperazin-1-yl)hexan-2-yl]amino]-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide;hydrochloride; Olcegepant (hydrochloride); Olcegepant hydrochloride
Solubility:
H2O: ≥ 66.66 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
InChIKey:
GJAWDDNZNYEKMO-XWIRJDCTSA-N
InChI:
1S/C38H47Br2N9O5.ClH/c39-29-21-25(22-30(40)34(29)50)23-33(45-37(53)48-15-10-28(11-16-48)49-24-26-5-1-2-6-31(26)44-38(49)54)35(51)43-32(7-3-4-12-41)36(52)47-19-17-46(18-20-47)27-8-13-42-14-9-27;/h1-2,5-6,8-9,13-14,21-22,28,32-33,50H,3-4,7,10-12,15-20,23-24,41H2,(H,43,51)(H,44,54)(H,45,53);1H/t32-,33+;/m0./s1
Canonical SMILES:
C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6.Cl
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CAS 586368-06-1 Olcegepant hydrochloride

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