|Description||Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors.|
A labelled form of Ziprasidone which is an antagonist of both 5-HT and dopamine receptor and it has been studied to show effective antipsychotic activity.
Naftidrofuryl, being useful in enhancing cellular oxidative, could be used as a vasodilator in the treatment of peripheral and cerebral vascular disorders.
Loxapine is a typical antipsychotic medication, used primarily in the treatment of schizophrenia and it is a D2/D4 dopamine receptor antagonist; 5-HT2A/2B, 5-H7...
The mesylate salt form of Dolasetron which is a pseudopelletierine derivative and could be used to relieve the nausea and vomiting caused by chemotherapy for be...
Granisetron is an antagonist of serptpmom 5-HT3 receptor and could be used to relieve the nausea and vomiting symptom after receving chemotherapy by decreasing ...
The maleic acid salt form of Alosetron which is an effective 5-HT3 receptor antagonist and could be commonly used against irritable bowel syndrome.
GMC 1-165 is an analogue of clozapine with 5-HT2A/2C and hM1 receptor affinities.
SB 242084 hydrochloride
SB 242084 hydrochloride is a selective and brain penetrant 5-HT2C receptor antagonist with over 100-fold selectivity versus a range of other 5-HT, dopamine and ...
Velusetrag is a selective, 5-HT4receptor agonist. Phase II clinical trials for the treatment of gastroparesis are on-going. Clnical trials for Alzheimer's disea...
Sarizotan, also known as EMD-128130, is a full 5-HT1a agonist and a dopamine D2-like agonist/partial agonist used in clinical trials for the treatment of l-dopa...
Eletriptan is Serotonin 1D receptor agonist originated by Pfizer. It is a second generation triptan drug. It is used as an abortive medication, blocking a migra...
MIN-101, a novel cyclic amide derivative, is a 5-HT2A and sigma 2 receptor antagonist (Ki= 7.53 nM for 5-HT2A and 8.19 nM for sigma-2, respectively).
Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. It is used mainly as a...
Eptapirone, a triazine derivative, has been found to be a 5-HT1A receptor agonist and was once studied as an antidepressant agent. pKi: 8.33.
8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor...
desmethyl-WAY 100635 trihydrochloride
desmethyl-WAY 100635 trihydrochloride is a precursor for labeling the 5-HT1A antagonist WAY 100635 and can be used for PET radioligand.
Lu AE58054 HCl salt
Lu AE58054 hydrochloride is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM.
This active molecular is a serotonin 5-HT1A antagonist. LY 206130 (3.0 mg/kg, s.c.) alone significantly increased norepinephrine level by 60%, dopamine levels b...
The hydrochloride salt form of Ziprasidone which is an antagonism of both serotonin and dopamine receptor and could be effective against schizophrenia.
LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki...