|Description||Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors.|
Adoprazine, also known as SLV 313, with potential antipsychotic property, is a agonist of cloned h5-HT(1A) receptors (pEC(50)=9.0) and a full antagonist of hD(2...
Rizatriptan Benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.
Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Ag...
Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo with psychostimulant, anti-ulcer and anti-emetic properties.
8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor...
Lisuride, an indoloquinoline derivative, has been found to be a dopamine D2 receptor agonist and could probably be effective in antimigraine as well as antipark...
Asenapine Maleate is a 5-HT receptor antagonist used for the treatment of acute schizophrenia and bipolar mania. It is a second-generation (atypical) antipsycho...
Naronapride is a selective 5-HT(4) receptor agonist for gastrointestinal motility disorders. It can accelerate overall colonic transit and tend to accelerate GE...
LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki...
LY 125180 is a serotonin antagonist.It can effect on serotonin uptake and serotonin synthesis in rat brain in vitro and in vivo.
The citrate salt form of tandospirone, a partial 5HT1A receptors agonist, could be effective as an antianxiety and antidepressant agent.
Cisapride is a drug that increases motility in the upper gastrointestinal tract and is used as a Gastroprokinetic. It acts directly as a serotonin 5-HT4 recepto...
GYKI-46903 is a Muscarinic M3 receptor and Serotonin 3 receptor antagonist. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron bind...
The maleic acid salt form of Alosetron which is an effective 5-HT3 receptor antagonist and could be commonly used against irritable bowel syndrome.
Elzasonan, also called as CP 448187, exhibits potent and selective antagonism of 5-HT1B receptors in vitro, and preclinical in vivo studies demonstrate enhanced...
Cisapride, also called as R51619, is a serotonin 5-HT4 receptor agonist used as a gastroprokinetic agent. Cisapride stimulates gastrointestinal motility, probab...
Methysergide is an ergot derivative that is a congener of lysergic acid diethylamide for the treatment of vascular headache
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist for 5-HT ( IC50= 0.95 ± 0.12 nM ), and also exhibits agonist activity at dopamine ...
The hydrochloride salt form of Alosetron which is an effective 5-HT3 receptor antagonist and could be commonly used against irritable bowel syndrome.