Olanzapine - CAS 132539-06-1
Catalog number: 132539-06-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H20N4S
Molecular Weight:
312.43975
COA:
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Targets:
5-HT Receptor
Description:
Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors.
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Purity:
>98%
Synonyms:
LY170053
MSDS:
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1.[Ultrastructural changes of lymphocytes in patients with schizophrenia treated with olanzapine].
Bonartsev PD1, Rakhmanova VI1, Uranova NA1. Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(3):49-54.
in English, RussianЦель исследования — изучение влияния терапии оланзапином на ультраструктуру разных субпопуляций лимфоцитов и лимфобластов у больных шизофренией. Материал и методы. Проведено электронно-микроскопическое морфометрическое исследование лимфоцитов. Обследовали 56 больных после 8 нед лечения и 49 пациентов после 28 нед лечения. Сравнение проводили с результатами обследования до лечения 59 больных и 31 здорового. Определяли процентное содержание, ультраструктурные особенности и морфометрические параметры малых и больших лимфоцитов, больших активированных лимфоцитов и лимфобластов. Результаты и заключение. Установлено достоверное повышение процента малых лимфоцитов и снижение процента больших лимфоцитов при лечении оланзапином по сравнению с периодом до лечения. В процессе терапии увеличилась объемная фракция лизосом малых лимфоцитов, больших лимфоцитов и лимфобластов; объемная фракция митохондрий в лимфоцитах не менялась.
2.Clozapine-treated Patients Have Marked Gastrointestinal Hypomotility, the Probable Basis of Life-threatening Gastrointestinal Complications: A Cross Sectional Study.
Every-Palmer S1, Nowitz M2, Stanley J3, Grant E4, Huthwaite M5, Dunn H6, Ellis PM5. EBioMedicine. 2016 Feb 15;5:125-34. doi: 10.1016/j.ebiom.2016.02.020. eCollection 2016.
BACKGROUND: Gastrointestinal side effects are particularly common with clozapine and occur with other antipsychotics, ranging from mild constipation to fatal bowel obstruction and/or ischemia. While this adverse-effect spectrum has been attributed to 'gastrointestinal hypomotility', gastrointestinal transit times in antipsychotic-treated patients have not previously been measured, making this mechanism speculative.
3.Atypical antipsychotic medications and hyponatremia in older adults: a population-based cohort study.
Gandhi S1, McArthur E2, Reiss JP3, Mamdani MM4, Hackam DG5, Weir MA1, Garg AX6. Can J Kidney Health Dis. 2016 Apr 11;3:21. doi: 10.1186/s40697-016-0111-z. eCollection 2016.
in English, FrenchMISE EN CONTEXTE: De nombreux exposés de cas font état d’une possible corrélation entre la prise de médicaments antipsychotiques atypiques et l’hyponatrémie. Or actuellement, il n’existe aucune évaluation fiable qui vienne corroborer cette association.
4.Olanzapine May Inhibit Colonic Motility Associated with the 5-HT Receptor and Myosin Light Chain Kinase.
Zhang J1, Qiao Y2, Le J3, Sun D1, Guan Y4, Li Z4. Psychiatry Investig. 2016 Mar;13(2):232-8. doi: 10.4306/pi.2016.13.2.232. Epub 2016 Mar 23.
OBJECTIVE: To study whether the effects of olanzapine on gastrointestinal motility is related to the serotonin antagonism and myosin light chain kinase.
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CAS 132539-06-1 Olanzapine

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