OF-1 - CAS 919973-83-4
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
BET Bromodomain
OF-1 is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor with Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, respectively. Selectivity against other bromodomains is very good, in general >100-fold. OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 µM and also demonstrates accelerated FRAP recovery at 5 µM in the BRPF2 FRAP assay.
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Brife Description:
A potent and selective BRPF inhibitor
Solid powder
4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide; OF-1; OF1; OF 1.
Store in a cool and dry place (or refer to the Certificate of Analysis).
Canonical SMILES:
1.Development of a commercial scale process for production of 1,4-butanediol from sugar.
Burgard A1, Burk MJ2, Osterhout R1, Van Dien S1, Yim H1. Curr Opin Biotechnol. 2016 Apr 28;42:118-125. doi: 10.1016/j.copbio.2016.04.016. [Epub ahead of print]
A sustainable bioprocess for the production of 1,4-butanediol (BDO) from carbohydrate feedstocks was developed. BDO is a chemical intermediate that goes into a variety of products including automotive parts, electronics, and apparel, and is currently manufactured commercially through energy-intensive petrochemical processes using fossil raw materials. This review highlights the development of an Escherichia coli strain and an overall process that successfully performed at commercial scale for direct production of bio-BDO from dextrose. Achieving such high level performance required an integrated technology platform enabling detailed engineering of enzyme, pathway, metabolic network, and organism, as well as development of effective fermentation and downstream recovery processes.
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CAS 919973-83-4 OF-1

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