Octenidine - CAS 71251-02-0
Catalog number: 71251-02-0
Category: APIs
Molecular Formula:
Molecular Weight:
OCTENIDINE; N,N’-[1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene]-bis(1-octanamine); NeoKodan; Octeniderm; Octenisept; Win-41464; Win-41464-2; 1,1'-Decamethylenebis(1,4-dihydro-4-(octylimino)pyridine)
Data not available, please inquire.
Boiling Point:
609.3ºC at 760 mmHg
Melting Point:
0.94 g/cm3
1.Octenidine dihydrochloride: chemical characteristics and antimicrobial properties.
Assadian O1. J Wound Care. 2016 Mar;25 Suppl 3:S3-6. doi: 10.12968/jowc.2016.25.Sup3.S3.
The empiric use of antibiotics is being restricted due to the spread of antimicrobial resistance. However, topical antiseptics are less likely to induce resistance, owing to their unspecific mode of action and the high concentrations in which they can be used. One such antiseptic, octenidine dihydrochloride (OCT), can be used either prophylactically or therapeutically on the skin, mucosa and wounds. Evidence to support its use comes from in-vitro, animal and clinical studies on its safety, tolerability and efficacy. This article summarises the physical, chemical and antimicrobial properties of OCT in the context of wound care.
2.Impact of a modified Broviac maintenance care bundle on bloodstream infections in paediatric cancer patients.
Furtwängler R1, Laux C1, Graf N1, Simon A1. GMS Hyg Infect Control. 2015 Nov 16;10:Doc15. doi: 10.3205/dgkh000258. eCollection 2015.
in English, GermanHintergrund: Während der intensiven Chemotherapie sind bei Kindern mit Krebserkrankungen Blutstrominfektionen (BSI) eine potentiell lebensbedrohliche Komplikation. Die meisten Patienten haben einen dauerhaft implantierten oder getunnelten zentralen Venenkatheter (CVAD, z.B. Broviac). Ein verbessertes Protokoll der Erhaltungspflege kann möglicherweise die Rate von BSI senken. Methode: Interventionsstudie zum Nutzen eines modifizierten Präventionsbündels in zwei prospektiven Beobachtungszeiträumen (P1: bis 05-2011; P2: 09-2011 bis 05-2013); prospektive Surveillance aller mikrobiologisch gesicherten BSI. In P2 wurden fertig konfektionierte NaCl 0.9% Spritzen (10 ml) zum Spülen des Broviacs verwendet. Außerdem wurden alle Konnektions- und Zuspritzstellen (Dreiwegehähne) mit Octenidin/Propanol desinfiziert.Ergebnisse: Während P1 wurden 84 Patienten und während P2 81 eingeschlossen. Die beiden Patientenpopulationen zeigten keine signifikanten Unterschiede in Bezug auf das Alter, die Grunderkrankung oder ihren Status (Anteil mit Rezidiv).
3.Antibacterial and antiplaque efficacy of a commercially available octenidine-containing mouthrinse.
Welk A1, Zahedani M2, Beyer C3, Kramer A4, Müller G4. Clin Oral Investig. 2015 Nov 10. [Epub ahead of print]
OBJECTIVES: The purpose of this clinical study was to determine the antibacterial and antiplaque efficacy of a recently introduced octenidine-containing mouthrinse (Octenidol®) in comparison with established antiseptic mouthrinses.
4.Antimicrobial efficiency of mouthrinses versus and in combination with different photodynamic therapies on periodontal pathogens in an experimental study.
Decker EM1, Bartha V1, Kopunic A1, von Ohle C1. J Periodontal Res. 2016 Apr 1. doi: 10.1111/jre.12379. [Epub ahead of print]
BACKGROUND AND OBJECTIVE: In the therapy of destructive periodontal disease, chemical antimicrobial agents and increasingly photodynamic therapy (PDT) play an important adjunctive role to standard mechanical anti-infective treatment procedures. However, both antiseptic methods have their shortcomings in terms of eliminating periodontal pathogens. The aim of the study was to compare the antibacterial efficacy of different antiseptic mouthrinses, of a conventional and a new, modified PDTplus as well as of the different antiseptic mouthrinses combined with either the conventional or the modified PDTplus against periopathogens.
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