|Description||OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM.|
Prostaglandin-E1 is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It can be used as a vasodilator agent increasing pe...
PF-04217329 is a potent and selective EP2 receptor agonist on intraocular pressure in preclinical models of glaucoma. It is a prodrug of CP-544326. It is well t...
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
Misoprostol, a synthetic analog of natural prostaglandin E1, is an effective anti-ulcer agent and also has oxytocic properties.
Fevipipran is a reversible competitive CRTh2 antagonist with IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood. ...
CP 544326, also known as taprenepag, is a potent and selective EP(2) receptor agonist. Its EC50 value is 2.8 nM. It is the active acid metabolite of the prodrug...
A EP1 antagonist (pKi= 7.54) (pIC50= 8.5)
Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhe...
GSK-345931A is an EP(1) receptor antagonist. It is efficient in preclinical models of inflammatory pain.
(+)-Cloprostenol sodium salt
(+)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol, which is an aryl-oxymethyl analog of prostaglandin F2α. It has luteolytic effects and is used ...
CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist. It inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It ...
ONO-AE3-208 is an EP4 antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively), which less potently affects EP3, FP, a...
MF592 is a potent and selective antagonists of the EP4 receptor. It has good functional potency and potent inhibition of PGE2 modulated TNFa release in LPS stim...
This active molecular is a prostaglandin receptor agonist and detailed information has not been published yet.
CP-533536, also called as Evatanepag, a 3-pyridyl sulfonamide compound, demonstrated excellent in vitro potency against prostaglandin E2 (PGE2) (induces local b...
Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 indu...
Grapiprant, also known as CJ-023,423, RQ-00000007 and AAT-007, is a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic prop...
FR-181157 is an orally active prostacyclin mimetic that shows high potency and agonist efficacy at the IP receptor.
MK-2894, a nonacylsulfonamide analogue, is a high affinity full antagonist against the EP4 receptor. It is found to have conceivable potency and selectivity for...
BW 245C, a prostaglandin analogue, is a selective prostanoid DP-receptor (DP1)agonist used to treat stroke where the Ki for the inhibition of [3H]-PGD2 binding ...