OAT-889
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
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Targets:
acidic mammalian chitinase (AMCase), chitotriosidase-1 (CHIT1)
Description:
OAT-889 is a dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase-1 (CHIT1) (hAMCase IC50 = 9 nM;hCHIT1 IC50 = 26 nM), which has the potential to treat asthma. OAT-889 reduced the number of infiltrating leukocytes in bronchoalveolar lavage fluid (BALF) in an acute mouse model of lung inflammation, as well as decreased mRNA of proinflammatory cytokines, such as interleukin-13, interleukin-1 and Muc5AC in lung tissue.
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Brife Description:
dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase-1 (CHIT1), asthma
MSDS:
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Application:
the treatment of asthma
Current Developer:
OncoArendi Therapeutics
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