O-Desmethyl Mebeverine Acid - CAS 586357-02-0
Catalog number:
586357-02-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H23NO3
Molecular Weight:
265.35
COA:
Inquire
Targets:
Others
Description:
O-Desmethyl Mebeverine Acid is a metabolite of Mebeverine, which is an antispasmodic.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥95%
Appearance:
Off-White to Pale Beige Solid
Synonyms:
Mebeverine metabolite O-desmethyl Mebeverine acid; 4-[Ethyl[2-(4-hydroxyphenyl)-1-methylethyl]amino]butanoic Acid
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A metabolite of Mebeverine
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
>185°C (dec.)
InChIKey:
DJTCBAFIXOMULT-UHFFFAOYSA-N
InChI:
1S/C15H23NO3/c1-3-16(10-4-5-15(18)19)12(2)11-13-6-8-14(17)9-7-13/h6-9,12,17H,3-5,10-11H2,1-2H3,(H,18,19)
Canonical SMILES:
CCN(CCCC(=O)O)C(C)CC1=CC=C(C=C1)O
1.Studies on the Biotransformation of Veratric Acid, a Human Metabolite of Mebeverine, by Using the Incubated Hen's Egg.
Kiep L1, Göhl M2, Schmidt J3, Seifert K2. Drug Res (Stuttg). 2015 Sep;65(9):500-4. doi: 10.1055/s-0034-1390457. Epub 2014 Oct 13.
Metabolism studies with selected test substances have shown that a model on the basis of the incubated hen's egg is suitable as a supplement to animal experimentation. Because of its 3,4-dimethoxyphenyl structure veratric acid (3,4-dimethoxybenzoic acid), a known human metabolite of mebeverine, was chosen as model substance for the present investigations and the parent compound as well as 4-hydroxy-3-methoxybenzoic acid were identified as main metabolites. The absence of 3-hydroxy-4-methoxybenzoic acid lets conclude that the O-demethylation takes place exclusively at the p-methoxyl function. In addition, 3,3',4,4'-tetramethoxy-l-ornithuric acid (2,5-bis-(3,4-dimethoxybenzoylamino)pentanoic acid) and its O-desmethyl derivative could be characterized as further metabolites. So far an amino acid conjugate has not been described after veratric acid administration in a vertebrate. There were no indications for the appearance of 3,4-dihydroxybenzoic acid in the veratric acid metabolism.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 491-54-3 Kaempferide

Kaempferide
(CAS: 491-54-3)

Kaempferide is an O-methylated flavonol. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L...

CAS 891025-25-5 BAMB-4

BAMB-4
(CAS: 891025-25-5)

BAMB-4 is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA). It exhibits the lowest inhibition frequency among the InsP...

CAS 1005491-05-3 Tirasemtiv

Tirasemtiv
(CAS: 1005491-05-3)

Tirasemtiv is a a small-molecule fast-skeletal-troponin activator, which is being developed as a potential treatment for diseases and conditions associated with...

Pocapavir
(CAS: 146949-21-5)

Pocapavir has been found to be an antienterovirus agent that could probably be effctive against enterovirus infections. The Phase-II trial for Poliomyelitis has...

CAS 79778-41-9 Neridronate

Neridronate
(CAS: 79778-41-9)

Neridronic acid is a Bone resorption factor inhibitor and it can be used to treat Osteogenesis imperfecta and Paget's disease of bone.

CAS 97759-16-5 S186

S186
(CAS: 97759-16-5)

S186 is a kind of sodium salts of calcium-acetylpropylamine phosphonate(APA). It is a new strontium-specific chelating agent. It has also been approved by Shang...

CAS 125-03-1 Hydrocortamate hydrochloride

Hydrocortamate hydrochloride
(CAS: 125-03-1)

This active molecular is a synthetic glucocorticoid with immunosuppressive and anti-inflammatory properties. Hydrocortamate hydrochloride is applicated for the ...

CAS 1743-60-8 (beta)-Estradiol 17-acetate

(beta)-Estradiol 17-acetate
(CAS: 1743-60-8)

β-Estradiol 17-acetate is a metabolite of estradiol.

CAS 70356-09-1 Avobenzone

Avobenzone
(CAS: 70356-09-1)

Avobenzone is an oil soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays and a dibenzoylmethane derivative.

CAS 1035979-44-2 P005672 HCl

P005672 HCl
(CAS: 1035979-44-2)

P005672 HCl is a novel, tetracycline-substituted, narrow-spectrum antibiotic compound used for treatment of bacterial infections and neoplasms. It is developed ...

CAS 3685-84-5 Meclofenoxate hydrochloride

Meclofenoxate hydrochloride
(CAS: 3685-84-5)

Meclofenoxate (Lucidril), also known as centrophenoxine, is a drug used to treat the symptoms of senile dementia and Alzheimer's disease. It is an ester of dime...

CAS 107868-30-4 Exemestane

Exemestane
(CAS: 107868-30-4)

Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

CGP 76030
(CAS: 497152-38-2)

CGP76030 is a ual-specific Src and Abl kinase inhibitor, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases.

CAS 4884-68-8 Hydrastinine hydrochloride

Hydrastinine hydrochloride
(CAS: 4884-68-8)

Hydrastinine hydrochloride is a semisynthetic alkaloid as a haemostatic drug.

CAS 98-92-0 Nicotinamide

Nicotinamide
(CAS: 98-92-0)

Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an activator of sirtuins.

CI 750
(CAS: 47739-68-4)

CI-750 is a novel antidiarrheal agent.

CAS 1208313-97-6 Ketone Ester

Ketone Ester
(CAS: 1208313-97-6)

a ketone ester given orally as R,S-1,3-butanediol acetoacetate diester (BD-AcAc(2)) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Ad...

CAS 70801-02-4 Flutroline

Flutroline
(CAS: 70801-02-4)

Flutroline is a γ-carboline antipsychotic agent. It is safe and efficient.

CAS 58-96-8 Uridine

Uridine
(CAS: 58-96-8)

Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

CAS 1916571-90-8 NCT-503

NCT-503
(CAS: 1916571-90-8)

NCT-503 is a non-competitive phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50= 2.5 µM), reducing the production of glucose-derived serine in cells and sup...

Chemical Structure

CAS 586357-02-0 O-Desmethyl Mebeverine Acid

Quick Inquiry

Verification code

Featured Items