O-Desmethyl Mebeverine Acid - CAS 586357-02-0
Catalog number: 586357-02-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H23NO3
Molecular Weight:
265.35
COA:
Inquire
Targets:
Others
Description:
O-Desmethyl Mebeverine Acid is a metabolite of Mebeverine, which is an antispasmodic.
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Purity:
≥95%
Appearance:
Off-White to Pale Beige Solid
Synonyms:
Mebeverine metabolite O-desmethyl Mebeverine acid; 4-[Ethyl[2-(4-hydroxyphenyl)-1-methylethyl]amino]butanoic Acid
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A metabolite of Mebeverine
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
>185°C (dec.)
InChIKey:
DJTCBAFIXOMULT-UHFFFAOYSA-N
InChI:
1S/C15H23NO3/c1-3-16(10-4-5-15(18)19)12(2)11-13-6-8-14(17)9-7-13/h6-9,12,17H,3-5,10-11H2,1-2H3,(H,18,19)
Canonical SMILES:
CCN(CCCC(=O)O)C(C)CC1=CC=C(C=C1)O
1.Studies on the Biotransformation of Veratric Acid, a Human Metabolite of Mebeverine, by Using the Incubated Hen's Egg.
Kiep L1, Göhl M2, Schmidt J3, Seifert K2. Drug Res (Stuttg). 2015 Sep;65(9):500-4. doi: 10.1055/s-0034-1390457. Epub 2014 Oct 13.
Metabolism studies with selected test substances have shown that a model on the basis of the incubated hen's egg is suitable as a supplement to animal experimentation. Because of its 3,4-dimethoxyphenyl structure veratric acid (3,4-dimethoxybenzoic acid), a known human metabolite of mebeverine, was chosen as model substance for the present investigations and the parent compound as well as 4-hydroxy-3-methoxybenzoic acid were identified as main metabolites. The absence of 3-hydroxy-4-methoxybenzoic acid lets conclude that the O-demethylation takes place exclusively at the p-methoxyl function. In addition, 3,3',4,4'-tetramethoxy-l-ornithuric acid (2,5-bis-(3,4-dimethoxybenzoylamino)pentanoic acid) and its O-desmethyl derivative could be characterized as further metabolites. So far an amino acid conjugate has not been described after veratric acid administration in a vertebrate. There were no indications for the appearance of 3,4-dihydroxybenzoic acid in the veratric acid metabolism.
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CAS 586357-02-0 O-Desmethyl Mebeverine Acid

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