Nylidrin hydrochloride - CAS 849-55-8
Catalog number: 849-55-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Adrenergic Receptor
Nylidrin hydrochloride is a beta-adrenergic agonist. It was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices. It causes peripheral vasodilation, a positive inotropic effect, and increases gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor. It also can be used as antiallergic agent. It is one of the FDA approved drug as Inhibitors of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP).
Off-White Solid
1-p-Hydroxyphenyl-2-(1’-methyl-3’-phenylpropylamino)-1-propanolhydrochloride;Arlidin hydrochloride;Buphenine hydrochloride;Dilatol hydrochloride;p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-benzylalcohohyd;Suprifenpsb hydrochloride;4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol;hydrochloride;Dilatyl
Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Nylidrin hydrochloride is used in the treatment of peripheral vascular disorders and premature labor. It also can be used as antiallergic agent.
Quality Standard:
USP standard
Shelf Life:
2 month in rt, long time
Melting Point:
198-199 °C (decomp)
Canonical SMILES:
1.Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.
Tamiz AP1, Whittemore ER, Zhou ZL, Huang JC, Drewe JA, Chen JC, Cai SX, Weber E, Woodward RM, Keana JF. J Med Chem. 1998 Aug 27;41(18):3499-506.
A series of bis(phenylalkyl)amines, structural analogues of ifenprodil and nylidrin, were synthesized and tested for antagonism of N-methyl-D-aspartate (NMDA) receptors. Potency and subunit selectivity were assayed by electrical recordings in Xenopus oocytes expressing three binary combinations of cloned rat NMDA receptor subunits: NR1A expressed in combination with either NR2A, NR2B, or NR2C. The bis(phenylalkyl)amines were selective antagonists of NR1A/2B receptors. Assayed under steady-state conditions, the most potent of these, N-[2-(4-hydroxyphenyl)ethyl]-5-phenylpentylamine hydrochloride (20), has an IC50 value of 8 nM and >1000-fold selectivity with respect to NR1A/2A and NR1A/2C receptors. The structure-activity relationship of the bis(phenylalkyl)amine series indicates that the piperidine ring and alkyl chain substitutions common to NR2B-selective antagonists such as ifenprodil, CP 101,606, and Ro 25-6981 are not necessary to generate potent and selective ligands.
2.Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials.
Bartlett H1, Eperjesi F. Ophthalmic Physiol Opt. 2003 Sep;23(5):383-99.
Age-related macular degeneration (AMD) is the leading cause of severe vision loss in the developed world. The lack of effective treatment modalities, coupled with evidence supporting an oxidative pathogenesis, has increased interest in the potential preventative role of nutritional supplementation. This article reviews seven randomised controlled trials (RCTs) that have investigated the role of nutritional supplementation in AMD. Three of these trials reported a positive effect of nutritional supplementation on AMD; the Age-related eye study (AREDS), the Lutein Antioxidant Supplementation Trial (LAST), and the oral zinc trial by Newsome et al. (1988). However, the oral zinc trial by Newsome et al. (1988) was unlikely to detect any difference between treatments smaller than 72%, and the AREDS results were based on a subgroup of their study population. Lutein was considered for the AREDS formulation, but was not commercially available at that time.
3.[Clinical trial on the effect of buphenine, aminophenazone and diphenylpyraline hydrochloride in treating the common cold in children of 6 to 24 months of age].
Montijo-Barrios E1, Cadena F, Ramírez-Mayans JA, Gutiérrez-Castrellón P. Rev Invest Clin. 2011 Jul-Aug;63(4):335-43.
INTRODUCTION: Acute respiratory infections are the second leading cause of morbidity in children under 18 years. Several drugs have been used with variable efficacy and safety, trying to reduce the associated symptoms and improve quality of life.
4.[3H]ifenprodil binding to NMDA receptors in porcine hippocampal brain membranes.
Höfner G1, Wanner KT. Eur J Pharmacol. 2000 Apr 14;394(2-3):211-9.
(+/-)-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propan-1-ol ([3H]ifenprodil) binding to a subcellular fraction of porcine hippocampus, which was obtained by centrifugation on a discontinuous sucrose gradient, was investigated with the objective to label selectively the ifenprodil recognition site of native NMDA receptors. Saturation experiments revealed high-affinity sites for [3H]ifenprodil in this membrane fraction which could be characterised by a K(d) value of 23.0+/-1.8 nM using a one-site model. Calculation of saturation isotherms on the basis of a two-site model yielded a K(d1) value of 10.4+/-2.4 nM and a K(d2) value of 2200+/-1300 nM, respectively. Inhibition of [3H]ifenprodil binding by NR2B subunit-selective NMDA receptor antagonists, by polyamines, by sigma receptor ligands, by a variety of ligands acting at different NMDA receptor recognition sites and by several cations was studied and compared with the effects of these compounds on (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine ([3H]MK-801) binding under non-equilibrium conditions.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products

CAS 65023-16-7 Bometolol Hydrochloride

Bometolol Hydrochloride
(CAS: 65023-16-7)

Bometolol is a beta-adrenergic blocking drug.

CAS 38339-11-6 Clenproperol

(CAS: 38339-11-6)

Clenproperol is a β-adrenergic agonist.

CAS 200050-59-5 L-771688

(CAS: 200050-59-5)

L-771688, also known as SNAP 6383, is a new potent and highly selective α1A-adrenoceptor antagonist with 500-fold selective over α1B and α1D-adrenoceptors.

CAS 498-45-3 Scopine

(CAS: 498-45-3)

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

(CAS: 508233-95-2)

Tedatioxetine is an antidepressant agent. It acts as a triple reuptake inhibitor and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. It was discov...

CAS 51-02-5 Pronethalol hydrochloride

Pronethalol hydrochloride
(CAS: 51-02-5)

Pronethalol hydrochloride is a β-adrenergic antagonist.

CAS 29122-68-7 Atenolol

(CAS: 29122-68-7)

Atenolol, with antianginal and antiarrhythmic properties, it is a cardioselective beta-adrenergic blocker and used in hypertension control.

CAS 856620-39-8 O-desmethyl Mebeverine alcohol hydrochloride

O-desmethyl Mebeverine alcohol hydrochlo
(CAS: 856620-39-8)

O-desmethyl Mebeverine alcohol hydrochloride, a metabolite of Mebeverine, is a potent inhibitor of α1 repector, causing relaxation of the gastrointestinal tract...

CAS 109544-45-8 RX 821002 hydrochloride

RX 821002 hydrochloride
(CAS: 109544-45-8)

RX 821002 hydrochloride is a selective and potent α2-adrenoceptor antagonist, which exhibits selectivity for the α2D over the α2A subtypes (pKd= 9.7 and 8.2 res...

CAS 94749-08-3 Salmeterol Xinafoate

Salmeterol Xinafoate
(CAS: 94749-08-3)

Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstru...

CAS 113145-69-0 (S)-(+)-Niguldipine hydrochloride

(S)-(+)-Niguldipine hydrochloride
(CAS: 113145-69-0)

(S)-(+)-Niguldipine hydrochloride, the more active enantiomer of Niguldipine hydrochloride, acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 n...

CAS 38241-28-0 Zinterol hydrochloride

Zinterol hydrochloride
(CAS: 38241-28-0)

Zinterol hydrochloride is a potent and selective β2-adrenoceptor agonist (pKB = 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery...

CAS 36067-72-8 B-HT 933 dihydrochloride

B-HT 933 dihydrochloride
(CAS: 36067-72-8)

B-HT 933 dihydrochloride is a selective α2-adrenoceptor agonist displaying 300-fold selectivity for the α2-adrenoceptor over the α1-adrenoceptor. B-HT 933 decre...

CAS 13392-18-2 Fenoterol

(CAS: 13392-18-2)

Fenoterol, a phenol derivative, is a β2-adrenoceptor agonist and could be used as a bronchodilator and an antiasthmatic.

(CAS: 170686-12-1)

BMS-194449 was found to be a β-adrenergic receptor agonist that was once studied in antihyperglycaemics as well as obesity therapy.

CAS 62929-91-3 Procaterol hydrochloride

Procaterol hydrochloride
(CAS: 62929-91-3)

Procaterol hydrochloride is a long-acting, very potent and specific beta-2-adrenergic receptor agonist. It acts as a vasodialator for long term treatment of ast...

CAS 63-92-3 Phenoxybenzamine HCl

Phenoxybenzamine HCl
(CAS: 63-92-3)

Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.

CAS 161905-64-2 α1 adrenoceptor-MO-1

α1 adrenoceptor-MO-1
(CAS: 161905-64-2)

An S enantiomer which has affinity at alpha 1 adrenergic receptor

CAS 6190-39-2 Dihydroergotamine mesylate

Dihydroergotamine mesylate
(CAS: 6190-39-2)

The mesylate salt form of Dihydroergotamine, which has been found to be a partial α-adrenergic agonist and could be used as an antimigraine agent.

CAS 81732-65-2 Bambuterol

(CAS: 81732-65-2)

Bambuterol is a long acting beta-adrenoceptor agonist (LABA) and is used in the treatment of asthma. It is an ester prodrug of the ß2-adrenergic agonist terbuta...

Chemical Structure

CAS 849-55-8 Nylidrin hydrochloride

Quick Inquiry

Verification code

Featured Items