NW457 - CAS 1373761-12-6
Catalog number:
1373761-12-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H32N2O7
Molecular Weight:
472.53
COA:
Inquire
Targets:
Hsp90
Description:
NW-457 is a potent Hsp90 inhibitor with no detectable hepatocytotoxicity in vitro. It synergizes with ionizing irradiation to induce chromatin condensation, nuclear fragmentation, apoptosis, and post-apoptotic, secondary necrosis. Enhanced apoptosis induction by NW457 in combination with irradiation is accompanied by increased caspase activation and caspase substrate cleavage.
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Brife Description:
NW-457 is a potent Hsp90 inhibitor with no detectable hepatocytotoxicity in vitro.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
1H-​2-​Benzoxacyclotetradec​in-​1,​11(12H)​-​dione, 3,​4,​7,​8-​tetrahydro-​7,​14,​16-​trihydroxy-​3-​methyl-​, 11-​[O-​[2-​oxo-​2-​(1-​piperidinyl)​ethyl]​oxime]​, (3S,​5E,​9E,​11E)​-
Storage:
3 years -20oC powder, 6 months-80oC in solvent.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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