NVP-BSK805 - CAS 1092499-93-8
Catalog number:
1092499-93-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H28F2N6O
Molecular Weight:
490.55
COA:
Inquire
Targets:
JAK
Description:
NVP-BSK805, a quinoxaline derivative, is a selective ATP-competitive JAK2 inhibitor which could induce apoptosis (GI50 < 100 nM) and restrain the growth of JAK2V617F cells (Ba/F3). IC50: 0.48 ± 0.02 nM (JAK2 JH1); 0.58 ± 0.03 nM (FL JAK2 wt).
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Purity:
98%
Appearance:
Powder
Synonyms:
NVPBSK805; NVP-BSK805; BSK805; BSK 805; 8-(3,5-DIFLUORO-4-(MORPHOLINOMETHYL)PHENYL)-2-(1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)QUINOXALINE
Solubility:
DMSO: 67 mg/mL; H2O: <1 mg/mL; EtOH: 7 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
NVP-BSK805 is a selective ATP-competitive JAK2 inhibitor which could induce apoptosis and restrain the growth of JAK2V617F cells.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
NUOCAPALWRHKCU-UHFFFAOYSA-N
InChI:
InChI=1S/C27H28F2N6O.2ClH/c28-23-12-18(13-24(29)22(23)17-34-8-10-36-11-9-34)21-2-1-3-25-27(21)33-26(15-31-25)19-14-32-35(16-19)20-4-6-30-7-5-20;;/h1-3,12-16,20,30H,4-11,17H2;2*1H
Canonical SMILES:
C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl
Current Developer:
NeuroVive
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CAS 1092499-93-8 NVP-BSK805

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