NVP-BGJ398 phosphate - CAS 1310746-10-1
Catalog number: 1310746-10-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H34Cl2N7O7P
Molecular Weight:
658.47
COA:
Inquire
Targets:
FGFR
Description:
Potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively); it showed siginificant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Infigratinib phosphate; BGJ-398 phosphate
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related FGFR Products


CAS 1035270-39-3 AZD-4547

AZD-4547
(CAS: 1035270-39-3)

AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. AZD4547 binds to and inhibi...

CAS 656247-17-5 Nintedanib

Nintedanib
(CAS: 656247-17-5)

Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59...

CAS 1708971-72-5 FGFR4-IN-1

FGFR4-IN-1
(CAS: 1708971-72-5)

FGFR4-IN-1 is a potent and selective FGFR4 inhibitor with potential for the treatment of gastric cancer.

CAS 848318-25-2 SSR128129E

SSR128129E
(CAS: 848318-25-2)

SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain with...

CAS 1708971-55-4 FGF-401

FGF-401
(CAS: 1708971-55-4)

FGF-401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) (IC50= 1.9 nM) developed for the treatment of solid tumor.

NSC12
(CAS: 102586-30-1)

NSC12 is an extracellular trap for fibroblast growth factor 2 (FGF2). It binds FGF2 with Kd value of 51 µM and interferes with its interaction with FGFR1 withou...

Fibroblast Growth Factor-Basic
(CAS: 106096-93-9)

Fibroblast Growth Factor-Basic is a growth factor encoded by the FGF2 gene. It is found in basement membranes and sub-endothelial extracellular matrix. FGF2 spe...

CAS 1125780-41-7 SKLB610

SKLB610
(CAS: 1125780-41-7)

SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth...

CAS 656247-18-6 BIBF 1120 esylate

BIBF 1120 esylate
(CAS: 656247-18-6)

Nintedanib esylate is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β.

CAS 1310746-10-1 NVP-BGJ398 phosphate

NVP-BGJ398 phosphate
(CAS: 1310746-10-1)

Potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1...

CAS 1265229-25-1 Debio-1347

Debio-1347
(CAS: 1265229-25-1)

Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and ...

CAS 1254473-64-7 LY2874455

LY2874455
(CAS: 1254473-64-7)

LY2874455 exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activit...

CAS 1058137-23-7 Lucitanib

Lucitanib
(CAS: 1058137-23-7)

Lucitanib, also known as E-3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor re...

CAS 219580-11-7 PD173074

PD173074
(CAS: 219580-11-7)

PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell prol...

CAS 326914-10-7 SU11652

SU11652
(CAS: 326914-10-7)

SU11652 is a cell-permeable and sunitinib-like inhibitor of tyrosine kinase receptor (RTK) and angiogenesis with antineoplastic property. It selectively inhibit...

S-49076
(CAS: 1265965-22-7)

This active molecular is a Axl receptor tyrosine kinase inhibitor, Proto oncogene protein c met inhibitor, Type-1, Type-2 and Type-3 fibroblast growth factor re...

CAS 1707289-21-1 BLU-554

BLU-554
(CAS: 1707289-21-1)

BLU-554 is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM), which is promisingly to be used for the treatment of h...

CAS 9050-30-0 Heparan Sulfate

Heparan Sulfate
(CAS: 9050-30-0)

Heparan sulfate, a complex and linear polysaccharide in which the backbone is composed of repeating sulfated disaccharide units, exists as part of glycoproteins...

E 3810 dihydrochloride

E 3810 dihydrochloride is a dual VEGFR/FGFR tyrosine kinase inhibitor. It suppresses the tumor angiogenesis and tumor cell proliferation via inhibiting VEGFR1, ...

CAS 872511-34-7 BGJ-398

BGJ-398
(CAS: 872511-34-7)

BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs...

Chemical Structure

CAS 1310746-10-1 NVP-BGJ398 phosphate

Quick Inquiry

Verification code

Featured Items