Nuclear Yellow - CAS 74681-68-8
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Nuclear yellow, as Hoechst S769121, belongs Hoechst stains, which were originally developed by Hoechst AG, which numbered all their compounds and are soluble in water and in organic solvents such as dimethyl formamide or dimethyl sulfoxide. It is the long-wavelength tracer and is often combined with the popular retrograde tracer true blue for two-color neuronal mapping. It exhibits excitation/emission maxima ~335/495 nm when bound to DNA. In neuronal cells, it primarily stains the nucleus with yellow fluorescence. It is stable when subjected to immunohistochemical processing and can be used to photoconvert DAB into an insoluble, electron-dense reaction product.
Publictions citing BOC Sciences Products
  • >> More
Light yellow powder
4-[6-[6-(4-Methyl-1-Piperazinyl)-1H-Benzimidazol-2-Yl]-1H-Benzimidazol-2-Yl]Benzenesulfonamide Trihydrochloride;4-(5-(4-Methyl-1-Piperazinyl)(2,5'-Bi-1H-Benzimidazol)-2'-Yl)Benzenesulfonamide Trihydrochloride;Hoe-S769121;2-(4-Sulfamylphenyl)-6-[6-(4-methylpiperazino)-2-benzimidazolyl]benzimidazole trihydrochloride
H2O: ≥ 6 mg/mL, DMSO: < 12.2 mg/mL
-20°C Freezer, Protect from light
Nuclear yellow exhibits excitation/emission maxima ~335/495 nm when bound to DNA. In neuronal cells, it primarily stains the nucleus with yellow fluorescence.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Boiling Point:
813.6°C at 760 mmHg
Canonical SMILES:
1.Growth-related changes in cell body size and succinate dehydrogenase activity of spinal motoneurons innervating the rat soleus muscle.
Ishihara A1, Kawano F, Ishioka N, Oishi H, Higashibata A, Shimazu T, Ohira Y. Int J Dev Neurosci. 2003 Dec;21(8):461-9.
Cell body sizes and oxidative enzyme (succinate dehydrogenase) activities of spinal motoneurons innervating the soleus muscle were determined in rats ranging in postnatal age from 3 to 13 weeks. The soleus motoneurons were labeled by a retrograde neuronal tracer, nuclear yellow. The mean cell body sizes of motoneurons increased from 3 to 7 weeks of age, while the mean succinate dehydrogenase activities of motoneurons decreased from 3 to 7 weeks of age. There were no changes in mean cell body size or mean succinate dehydrogenase activity of motoneurons from 7 to 13 weeks of age. An inverse relationship between cell body size and succinate dehydrogenase activity of motoneurons was observed, irrespective of age. These results indicate that motoneurons innervating the rat soleus muscle show the adult pattern of cell body size and succinate dehydrogenase activity at an earlier stage of postnatal growth, 7 weeks of age.
2.Fusion body formation, germ tube anastomosis, and nuclear migration during the germination of urediniospores of the wheat leaf rust fungus, Puccinia triticina.
Wang X1, McCallum B. Phytopathology. 2009 Dec;99(12):1355-64. doi: 10.1094/PHYTO-99-12-1355.
ABSTRACT Vegetative or parasexual recombination is thought to be a key mechanism for the genetic diversity of cereal rust fungi. The process of germ tube fusion leading to hyphal anastomosis and nuclear recombination was analyzed in wheat leaf rust fungus, Puccinia triticina. Germ tube anastomosis was observed in 27 P. triticina isolates, each representing a different virulence phenotype. Germ tube fusion bodies (GFBs), which appeared as viscid globules formed at tips of germ tubes, were essential for germ tube anastomosis. The formation of GFBs was affected by the urediniospore density and the length of illumination during germination. GFBs were formed at the highest frequency when urediniospores were spread to a concentration of 1 x 10(6) urediniospores/ml and incubated in dark for 12 to 24 h during germination. GFB attached to either the side of another germ tube ("tip to side") or to another GFB formed at the tip of a second germ tube ("tip to tip").
3.Cerebellar fastigial neurons send bifurcating axons to both the left and right superior colliculus in cats.
Katoh YY1, Benedek G. Brain Res. 2003 Apr 25;970(1-2):246-9.
Anesthetized cats were injected with 2% Fast Blue and 0.5% Nuclear Yellow into the intermediate and deep layers of the left and right superior colliculus, respectively. In the right caudal part of the cerebellar fastigial nucleus (cFN), double-labeling was found in 38.5% of the neurons labeled with Fast Blue, and in 11.5% of the neurons labeled with Nuclear Yellow. In the left cFN, 52.2% of the neurons labeled with Fast Blue and 11.0% of the neurons labeled with Nuclear Yellow were double-labeled. The results suggest a role of bifurcating fastigial fibers in cerebellar visual control.
4.Combining visual information from the two eyes: the relationship between isthmotectal cells that project to ipsilateral and to contralateral optic tectum using fluorescent retrograde labels in the frog, Rana pipiens.
Dudkin EA1, Sheffield JB, Gruberg ER. J Comp Neurol. 2007 May 1;502(1):38-54.
The frog nucleus isthmi (homolog of the mammalian parabigeminal nucleus) is a visually responsive tegmental structure that is reciprocally connected with the ipsilateral optic tectum; cells in nucleus isthmi also project to the contralateral optic tectum. We investigated the location of the isthmotectal cells that project ipsilaterally and contralaterally using three retrograde fluorescent label solutions: Alexa Fluor 488 10,000 mw dextran conjugate; Rhodamine B isothiocyanate; and Nuclear Yellow. Dye solutions were pressure-injected into separate sites in the superficial optic tectum. Following a 6-day survival, brains were fixed, sectioned, and then photographed. Injection of the different labels at separate, discrete locations in the optic tectum result in retrograde filling of singly labeled clusters of cells in both the ipsilateral and contralateral nucleus isthmi. Generally, ipsilaterally projecting cells are dorsal to the contralaterally projecting cells, but there is a slight overlap between the two sets of cells.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CK 683A
(CAS: 83539-21-3)

CK 683A is a bio-active chemical,but no detailed information has been published yet.

CAS 517-28-2 Hematoxylin

(CAS: 517-28-2)

Hematoxylin (Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain...

CAS 79350-37-1 Cefixime

(CAS: 79350-37-1)

Cefixime is an effective, orally active and a third generation cephalosporin antibiotic. It is useful for the treatment of a number of bacterial infections, suc...

CAS 153381-68-1 7-Epi-docetaxel

(CAS: 153381-68-1)

An isomer of Docetaxel (D494420). Docetaxel injection impurity C.

(CAS: 179054-51-4)

FR-182980, a pyridine derivative, has been found to be a sterol O-acyltransferase inhibitor and was once studied in hypercholesterolaemia.

(CAS: 109306-94-7)

LY-201409 is a potent benzamide anticonvulsant. It antagonized maximal electroshock (MES)-induced seizures with ED50 values of 16.2 and 4.2 mg/kg after oral adm...

CAS 30950-27-7 Perillartine

(CAS: 30950-27-7)

Perillartine, the a-syn-oxime 1 of perillaldehyde, is a sweetening agent which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-depend...

CAS 406-90-6 Flurossene

(CAS: 406-90-6)

Fluroxene is a volatile, inhalational anesthetic, and was the first halogenated hydrocarbon anesthetic to be introduced.

(CAS: 1623804-44-3)

Henagliflozin, a glucoside compound, has been found to be a sodium-glucose transporter 2 inhibitor that could probably be effective in hyperglycaemic. It is und...

CAS 1035979-44-2 P005672 HCl

P005672 HCl
(CAS: 1035979-44-2)

P005672 HCl is a novel, tetracycline-substituted, narrow-spectrum antibiotic compound used for treatment of bacterial infections and neoplasms. It is developed ...

CAS 739-71-9 trimipramine

(CAS: 739-71-9)

Trimipramine is a tricyclic antidepressant. It is serotonin and norepinephrine transport inhibitor with antipsychotic and sedative properties.

CAS 486-16-8 Carbinoxamine

(CAS: 486-16-8)

Carbinoxamine is a antihistamine and anticholinergic agent used in the treatment of severe itching in patients with CD5.

CAS 229476-53-3 EBE-A22

(CAS: 229476-53-3)

The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EG...

CAS 101387-97-7 Ro18-5362

(CAS: 101387-97-7)

Ro18-5362 is the less active prodrug of Ro 18-5364 which is an extremely potent and rapid inhibitor of the gastric mucosal (H+ + K+)-ATPase.

CAS 557-08-4 Zinc undecylenate

Zinc undecylenate
(CAS: 557-08-4)

Zinc undecylenate is a ungistatic fatty acid used in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

CAS 143982-31-4 LY 186564

LY 186564
(CAS: 143982-31-4)

LY 186564 is a bio-active chemical,but no detailed information has been published yet.

CAS 123-82-0 2-Aminoheptane

(CAS: 123-82-0)

2-Aminoheptane, a fatty Amine compound, is commonly used in proteomics research and could also be used to product some A3 adenosine receptor antagonists.

CAS 3734-80-3 Ocaphane

(CAS: 3734-80-3)

Ocaphane is a strong antitumor agent used on a number of animal tumors along with fairly toxic to hemopoietic organs.

CTX-0294885 hydrochloride

CTX-0294885 hydrochloride is the hydrochloride salt of CTX-0294885 which displays high affinity toward an extensive range of kinases. The evaluation of the bind...


TP508, also known as Chrysalin (OrthoLogic, Tempe, Arizona), is a 23 amino acid synthetic peptide representing residues 508-530 of human prothrombin. Studies ha...

Chemical Structure

CAS 74681-68-8 Nuclear Yellow

Quick Inquiry

Verification code

Featured Items