NU7441 - CAS 503468-95-9
Catalog number:
503468-95-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
ITK
Description:
NU7441 is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. NU7441 appreciably increased G(2)-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. In mice bearing SW620 xenografts, NU7441 concentrations in the tumor necessary for chemopotentiation in vitro were maintained for at least 4 hours at nontoxic doses. NU7441 increased etoposide-induced tumor growth delay 2-fold without exacerbating etoposide toxicity to unacceptable levels. In conclusion, NU7441 shows sufficient proof of principle through in vitro and in vivo chemosensitization and radiosensitization to justify further development of DNA-PK inhibitors for clinical use.
Publictions citing BOC Sciences Products
  • >> More
Purity:
0.98
Synonyms:
NU7441; NU-7441; NU 7441.
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related ITK Products


CAS 439575-02-7 BMS-509744

BMS-509744
(CAS: 439575-02-7)

BMS-509744 is a selective Itk inhibitor. It is useful for treatment of inflammatory and autoimmune diseases.

CAS 439574-61-5 ITK inhibitor

ITK inhibitor
(CAS: 439574-61-5)

ITK inhibitor is a potent inhibitor of ITK.

CAS 503468-95-9 NU7441

NU7441
(CAS: 503468-95-9)

NU7441 is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ioni...

GNE-9822
(CAS: 1557232-32-2)

GNE-9822, a pyrazole derivative, has been found to be a ITK inhibitor that could probably be effective in studies of some inflammatory disorders.

GNE-4997
(CAS: 1705602-02-3)

GNE-4997, a pyrazol derivative, has been found to be an ITK inhibitor that could have significant biological activities. Ki: 0.09 nM.

Chemical Structure

CAS 503468-95-9 NU7441

Quick Inquiry

Verification code

Featured Items