NU7026 - CAS 154447-35-5
Catalog number:
154447-35-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Targets:
DNA-PK
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1.Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
Ma H1, Takahashi A2, Yoshida Y3, Adachi A4, Kanai T5, Ohno T6, Nakano T7,8. Radiat Oncol. 2015 Nov 9;10:225. doi: 10.1186/s13014-015-0536-z.
BACKGROUND: Our previous data demonstrated that targeting non-homologous end-joining repair (NHEJR) yields a higher radiosensitivity than targeting homologous recombination repair (HRR) to heavy ions using DNA repair gene knockouts (KO) in mouse embryonic fibroblast (MEF). In this study, we determined if combining the use of an NHEJR inhibitor with carbon (C) ion irradiation was more efficient in killing human cancer cells compared with only targeting a HRR inhibitor.
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