NT113 - CAS 1398833-56-1
Catalog number: B0084-475403
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C27H25ClFN5O2
Molecular Weight:
505.98
COA:
Inquire
Targets:
EGFR
Description:
NT113 is a pan-ERBB inhibitor with high brain penetrance. It can inhibit the growth of glioblastoma xenografts with EGFR amplification. NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. NT113 can inhibit ERBB family member phosphorylation in vivo and vitro. It can also inhibit the phosphorylation of downstream signaling mediator Akt. No recent reports of development were identified for preclinical development in Glioblastoma in USA
Purity:
98%
Appearance:
Powder
Synonyms:
NT-004; NT 004; NT004; NT-113; NT 113; NT113; NT-125; NT 125; NT125; (E)-N-(7-(((1R,5S,6s)-3-oxabicyclo[3.1.0]hexan-6-yl)ethynyl)-4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Glioblastoma
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
O=C(/C=C/CN(C)C)NC1=C(C#C[C@H]2[C@H]3[C@@H]2COC3)C=C(N=CN=C4NC5=CC(Cl)=C(F)C=C5)C4=C1
Current Developer:
Jiangsu Kanion Pharmaceutical; NewGen Therapeutics
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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