NSC348884 - CAS 81624-55-7
Catalog number:
81624-55-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C38H40N10
Molecular Weight:
636.79
COA:
Inquire
Targets:
Nucleophosmin
Description:
NSC 348884 is a putative inhibitor of nucleophosmin (NPM). It is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a defined hydrophobic pocket required for oligomerization. It can inhibit cell proliferation,up-regulates p53 and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM. It disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay.
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine;1,2-EthanediaMine, N,N,N',N'-tetrakis[(5-Methyl-1H-benziMidazol-2-yl)Methyl]- ;N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine
Solubility:
DMSO: ≥ 34 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
NSC 348884 inhibits the formation of nucleophosmin dimers. It can inhibit cell proliferation,up-regulates p53 and induce apoptosis in various cancer cell line. It disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
1001.7±65.0 °C | Condition: Press: 760 Torr
Melting Point:
inhibitor of nucleophosmin (NPM)
Density:
1.347±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
KZOLQEUQAFTQFM-UHFFFAOYSA-N
InChI:
InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46)
Canonical SMILES:
CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C
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NSC348884
(CAS: 81624-55-7)

NSC 348884 is a putative inhibitor of nucleophosmin (NPM). It is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a defined hy...

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