|Description||NSC305787 hydrochloride is a small molecule inhibitor of PKC (IC50=8.3 μM) that directly inhibits ezrin protein as an approach to prevent tumor metastasis.|
|Synonyms||[2-(Adamantan-1-yl)-6,8-dichloro-4-quinolinyl](2-piperidinyl)methanol hydrochloride; [2-(Adamantan-1-yl)-6,8-dichloro-4-quinolinyl](2-piperidinyl)methanol hydrochloride|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||A small molecule inhibitor of PKC|
|Quality Standard||Enterprise Standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
[Glu27]-PKC (19-36) is the inactive single mutation control peptide for PKC (19-36), a pseudosubstrate peptide inhibitor of protein kinase C.
The Pharmacological activity of this molecular is Growth Inhibition of Malignant<br/>Cells in vivo and in vitro and cytotoxic properties may result inhibition<b...
CRT0066854 is a selective and ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM for full-length PKCζ, PKCι, respectively)....
Ro 31-8220 Mesylate
Ro 31-8220 inhibits rat brain PKC activity with IC50 of 23 nM, and does not show any high degree of selectivity between PKC-α, PKC-β, PKC-γ, and PKC-ε.
(±)-Palmitoylcarnitine chloride, a long-chain acylcarnitine with both intracellular and extracellular roles, has a wide range of biological actions including th...
PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 μM).
TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery. TAS-103 inhibits...
Ro 32-0432 hydrochloride
Ro 32-0432 hydrochloride is a selective and orally active inhibitor of PKC displaying a 10-fold greater selectivity for PKC-&alpha (IC50 = 9.3 nM); and a 4-fold...
Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-m...
[Ala113]-MBP (104-118) is a non-competitive inhibitor of PKC with IC50 value of 46-145 mM. It is a synthetic peptide analog of bovine myelin basic protein (MBP)...
LXS196 is a potent and orally active protein kinase C (PKC) inhibitor under clinical trials for the treatment of uveal melanoma, the most common cancer of the e...
The hydrochloride salt form of CRT 0066854, which has been found to be a PKC inhibitor.
Rottlerin, a principal phenolic compound of the Kamala plant Mallotus philippinensis, originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII....
GO6983 is a potent protein kinase C (PKC) inhibitor. GO6893 displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration...
Midostaurin is a multi-target protein kinase inhibitor being investigated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
SC-9 is a potent activator of protein kinase C in the presence of Ca2+.
Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins...
Ingenol, the analogue of Ingenol 3-Angelate found in the seeds of Euphorbia lathyris L, is an extremely weak PKC (protein kinase C) activator ( Ki=30 μM, ED50=2...
Phorbol, derived from the roots of Euphorbia pekinensis Rupr., as a tumor promoter it is able to activate protein kinase C.
Staurosporine is broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyr...