NSC305787 - CAS 785718-37-8
Catalog number:
785718-37-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H30Cl2N2O
Molecular Weight:
445.42
COA:
Inquire
Targets:
PKC
Description:
NSC305787 is a small molecule inhibitor of PKC. Its IC50 value is 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, moesin and radixin. It is proved a novel targeted therapy which could inhibit ezrin protein as an approach to prevent tumor metastasis in vitro. It could inhibited T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels and inhibit the lung metastases growth of high-ezrin-expressing K7M2 OS cells in this organ culture assay. It cause reduced cell motility phenotypes in zebrafish in vivo.
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Purity:
>98%
Appearance:
Solid powder
Solubility:
DMSO: 10 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
NSC305787 is proved a novel targeted therapy which could inhibit ezrin protein as an approach to prevent tumor metastasis in vitro. It could inhibited T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels and inhibit the lung metastases growth of high-ezrin-expressing K7M2 OS cells in this organ culture assay.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
597.2±45.0 °C | Condition: Press: 760 Torr
Density:
1.312±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChI:
InChI=1S/C25H30Cl2N2O/c26-17-8-18-19(24(30)21-3-1-2-4-28-21)10-22(29-23(18)20(27)9-17)25-11-14-5-15(12-25)7-16(6-14)13-25/h8-10,14-16,21,24,28,30H,1-7,11-13H2
Canonical SMILES:
OC(C1NCCCC1)C2=CC(C3(C4)CC5CC4CC(C5)C3)=NC6=C(Cl)C=C(Cl)C=C26
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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