NSC12 - CAS 102586-30-1
Catalog number:
102586-30-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H34F6O3
Molecular Weight:
484.52
COA:
Inquire
Targets:
FGFR
Description:
NSC12 is an extracellular trap for fibroblast growth factor 2 (FGF2). It binds FGF2 with Kd value of 51 µM and interferes with its interaction with FGFR1 without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans. It also binds several other FGF isoforms and prevents them from forming HSPG/FGF/FGFR ternary complexes. It inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice. It inhibited the proliferation of different FGF-dependent tumour cell lines, but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1. It was shown to inhibit FGFR phosphorylation, angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells in vivo. It has significant implications in cancer therapy.
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Purity:
>98 %
Appearance:
Solid powder
Synonyms:
21-(Hydroxy(bistrifluoromethyl)methyl)pregnane-3,20-diol;Pregn-5-ene-3,20-diol, 21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)-;LS-118618;4,4,4-Trifluoro-1-[(8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-3-(trifluoromethyl)butane-1,3-diol;NSC-12;NSC-172285;NSC172285;(R)-4,4,4-trifluoro-1-((3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-3-(trifluoromethyl)butane-1,3-diol
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
NSC12 has significant implications in cancer therapy.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
521.8±45.0 °C | Condition: Press: 760 Torr
Density:
1.31±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
OHKBOEWLASAFLW-DRPHTYIMSA-N
InChI:
InChI=1S/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14?,15-,16-,17-,18+,19?,20-,21-/m0/s1
Canonical SMILES:
CC12CCC3C(C1CCC2C(CC(C(F)(F)F)(C(F)(F)F)O)O)CC=C4C3(CCC(C4)O)C
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