NS 1643 - CAS 448895-37-2
Catalog number:
448895-37-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H10F6N2O3
Molecular Weight:
380.06
COA:
Inquire
Targets:
Potassium Channel
Description:
NS 1643 is human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM)
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Purity:
≥98 %
Appearance:
Off-white solid
Synonyms:
1,3-Bis(2-hydroxy-5-trifluoromethylphenyl)urea; N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
KV11.1 channel activator
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
NJFVQMRYJZHGME-UHFFFAOYSA-N
InChI:
1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
Canonical SMILES:
C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O
1.Mechanistic studies of the agmatine deiminase from <em>Listeria monocytogenes</em>.
Soares CA1, Knuckley B2. Biochem J. 2016 Mar 31. pii: BCJ20160221. [Epub ahead of print]
<em>Listeria monocytogenes</em> is a gram-positive, food borne pathogen that is capable of living within extreme environments (<em>i.e</em>., low temperatures and pH). This ability to survive in such conditions may arise, at least in part, from agmatine catabolism via the Agmatine Deiminase System (AgDS). This catabolic pathway utilizes an agmatine deiminase (AgD) to hydrolyze agmatine into N-carbamoylputrescine (NCP), with concomitant release of ammonia, which increases the pH, thus mitigating the ill effects of the acidic environment. Given the potential significance of this pathway for cell survival, we set out to study the catalytic mechanism of the AgD encoded by <em>L. monocytogenes</em>. Herein, we describe the catalytic mechanism employed by this enzyme based on pH profiles, p<em>K</em>ameasurements of the active site cysteine, and solvent isotope effects. In addition, we report inhibition of this enzyme by two novel AgD inhibitors, <em>i.
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CAS 448895-37-2 NS 1643

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