NS-018 - CAS 1239358-86-1
Catalog number: 1239358-86-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H20FN7
Molecular Weight:
389.43
COA:
Inquire
Targets:
JAK
Description:
NS-018, a selective JAK2 as well as Src family tyrosine kinases inhibitor that could probably induce the apoptosis of tumor cells. It is still under Phase I/II trial against Myelofibrosis. IC50: 470 nM for Ba/F3-JAK2V617F cell.
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Purity:
98%
Appearance:
Powder
Synonyms:
NS-018; UNII-56R994WX4L; 56R994WX4L; GTPL7839; SCHEMBL14954406; UQTPDWDAYHAZNT-AWEZNQCLSA-N
Solubility:
DMSO: ≥ 34 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
NS-018 is a selective JAK2 as well as Src family tyrosine kinases inhibitor that could probably induce the apoptosis of tumor cells.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
UQTPDWDAYHAZNT-AWEZNQCLSA-N
InChI:
InChI=1S/C21H20FN7/c1-14(15-3-5-18(22)6-4-15)26-19-9-16(17-11-25-29(2)13-17)10-20(27-19)28-21-12-23-7-8-24-21/h3-14H,1-2H3,(H2,24,26,27,28)/t14-/m0/s1
Canonical SMILES:
CC(C1=CC=C(C=C1)F)NC2=CC(=CC(=N2)NC3=NC=CN=C3)C4=CN(N=C4)C
Current Developer:
Nippon Shinyaku
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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