Noscapine hydrochloride - CAS 912-60-7
Catalog number: 912-60-7
Category: Inhibitor
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Molecular Formula:
C22H23NO7.HCl
Molecular Weight:
449.88
COA:
Inquire
Targets:
Microtubule/Tubulin
Description:
Noscapine hydrochloride, the hydrochloride salt form of Noscapine which binds to tubulin and arrests mammalian cells in mitosis at a concentration of 20 µM . Noscapine induces apoptosis (in HeLa cells: IC50 = 25 µM; in thymocytes: IC50 =10 µM) and inhibit CYP2C19 (IC50 = 400.3 nM (human)), HepG2 (IC50 >1000 nM (human)) and A549 (EC5050 = 25 µM (human)).
Brife Description:
Binds to tubulin; Arrests cells in mitosis; Induces apoptosis (in HeLa cells: IC50 = 25 µM; in thymocytes: IC50 =10 µM)
Appearance:
White solid
Synonyms:
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one; hydrate; hydrochloride; Narcotine hydrochloride; 912-60-7; C22H23NO7.ClH.H2O; 2579AH; D02172
Solubility:
Soluble to 50 mM in 1eq. HCl
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -64℃ for long term (months to years).
MSDS:
Inquire
Boiling Point:
565.3ºC at 760 mmHg
Melting Point:
221-223ºC
InChIKey:
ZYGSNVAGWKWKKI-WCRQIBMVSA-N
InChI:
1S/C22H23NO7.ClH.H2O/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H;1H2/t17-,18+;;/m1../s1
Canonical SMILES:
CN1CCC2=CC3=C(C(=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3.O.Cl
1.The antitussive and expectorant drug Duopect evaluated by the preferential test.
Wójcicki J;Szwed G;Drozdowska-Ksiazek D Arch Immunol Ther Exp (Warsz). 1976;24(4):549-52.
The effect of the preparation Duopect (narcotine hydrochloride + glyceryl guiacolate) on intensity and frequency of cough and expectoration was evaluated by the preferential test in 62 patients with chronic bronchitis. The preparation was compared to narcotine and to a placebo in a double-blind study. Duopect was found to be an effective antitussive and expectorant medicine with only minimal and transient side effects.
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CAS 912-60-7 Noscapine hydrochloride

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