Noscapine - CAS 128-62-1
Catalog number: 128-62-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Sigma Receptor
Noscapine is a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine binds to tubulin and alters its conformation, resulting in a disruption of the dynamics of microtubule assembly (by increasing the time that microtubules spend idle in a paused state) and, subsequently, the inhibition of mitosis and tumor cell death. Unlike other tubulin inhibitors such as the taxanes and vinca alkaloids, noscapine does not affect microtubule polymerization.
Publictions citing BOC Sciences Products
  • >> More
White Solid
CB-3304; alpha-Narcotine; Narcompren; Tusscapine; Narcosine; Terbenol; Opianin; Capval
Current Developer:
Cougar Biotechnology, Inc
1. Determination of Noscapine and Papaverine in Mixtures
Neelam Khanna, lshivar C. Varshney, Sadhana Banerjee* and Bajsang B. Singh. Analyst, Vol. 108
Noscapine was extracted with 20-, 10-, 10- and 5-ml portions of 4% sodium hydroxide solution. To the combined aqueous solution were added 10 ml of concentrated hydrochloric acid and the resulting acidic solution was transferred into a separating funnel and then rinsed with three successive 5-ml portions of water. About 10 ml of concentrated ammonia solution (27.0-30.0% m/V of ammonia, ca. 0.896 g ml-1) were added and the mixture was extracted with successive 20-, lo-, 10- and 5-ml portions of chloroform, washing each extract with the same 10ml of water. The chloroform extract was dried over anhydrous sodium sulphate, filtered, the sodium sulphate washed twice with 5 ml of chloroform, the washings were added to the extract, the solvent was distilled off and the contents were evaporated to dryness on a water-bath. The residue was dissolved in 10 ml of glacial acetic acid, 5 ml of acetic anhydride were added and the solution was titrated against 0.1 N perchloric acid using crystal violet as the indicator, the colour change being from violet to green. Each 1 ml of 0.1 N perchloric acid is equivalent to 0.04134 g of noscapine.
2. A high-throughput multi-class liquid chromatography tandem mass spectrometry method for quantitative determination of licit and illicit drugs in whole blood
Lambert K. Sørensen* and Jørgen B. Hasselstrøm. Anal. Methods, 2013, 5, 3185–3193
Calibrants based on blank donor blood from single persons were used for the construction of 5- to 6-point calibration curves. The samples were treated according to the same procedure except that 100 mL ofMeOH was replaced by 100 mLof the mixed standards of the drug substances. Concentrations in the original blood sample of 10, 100, 400, 800, 1200 and 1600 mg L-1 for chlordiazepoxide, citalopram, lidocaine, methadone, tramadol and O-desmethyltramadol; 2, 8, 16, 24 and 32 mg L-1for buprenorphine, norbuprenorphine, fentanyl, 6-MAM, noscapine, THC and THC-OH; 5, 20, 40, 60 and 80 mg L-1 for THC-COOH; and 5, 50, 200, 400, 600 and 800 mg L-1of the remaining substances were obtained. The SIL analogues were used in the quantification of all substances except noscapine and desmethylmirtazapine because SIL analogues of these substances were not commercially available at the time of the study. Instead, zolpidem-D6 andmirtazapine-D3 were used as IS for noscapine and desmethyl-mirtazapine, respectively.
3. Detection of drugs in latent fingermarks by mass spectrometric methods
Angelina Yimei Lim,* Frederick Rowell, Cheryl Grace Elumbaring-Salazar, Jason Lokee and Jan Ma. Anal. Methods, 2013, 5, 4378–4385
Redevelopment of pre-dusted (using Lightning silver/grey magnetic fingerprint powder) spiked lifted fingermarks by either re-dusting with silica-CB particles or spraying with silica-CB particle suspension resulted in the successful SALDI-MS detection of nicotine, noscapine and 6-MAM. Fig. 6 shows the SALDI-MS detection of noscapine at m/z 220 post-redevelopment. The noscapine peak was initially absent in the pre-dusted fingermark. Heroin was detected in the sprayed section of thefingermark as [M + Na]+ at m/z 392 but remained undetectable in the re-dusted section of the fingermark. It was observed that methadone did not require a matrix for SALDI-MS and could be detected in the Lightning silver/grey dusted lifted fingermark. Also, it was noted that redevelopment with silica-CB particles using either method did not improve the S/N value of the peak of interest for methadone.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sigma Receptor Products

CAS 878141-96-9 S1RA

(CAS: 878141-96-9)

CAS 932736-91-9 (±)-PPCC oxalate

(±)-PPCC oxalate
(CAS: 932736-91-9)

(±)-PPCC oxalate is a selective sigma (σ) receptor ligand, which is noted to exhibit high affinity for σ1 and also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM re...

Siramesine hydrochloride
(CAS: 224177-60-0)

Siramesine hydrochloride is the hydrochloride salt form of Siramesine. Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in v...

CAS 138356-21-5 BD 1047 dihydrobromide

BD 1047 dihydrobromide
(CAS: 138356-21-5)

The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schi...

CAS 147817-50-3 Siramesine

(CAS: 147817-50-3)

Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in vivo. It was originally devevloped for treating depressant and it has pr...

CAS 97-39-2 DTG

(CAS: 97-39-2)

DTG has been found to be a σ-receptor agonist and is useful in studies of its interaction with dopamine drug.

CAS 207455-21-8 L-693,403 maleate

L-693,403 maleate
(CAS: 207455-21-8)

L-693,403 maleate is the maleate salt of L-693,403, which is a sigma receptor-binding compound. It has excellent selectivity over the dopamine D2 receptor and b...

CAS 138356-09-9 BD 1008 dihydrobromide

BD 1008 dihydrobromide
(CAS: 138356-09-9)

BD 1008 dihydrobromide is a potent and selective σ receptor antagonist displaying 4-fold selectivity for σ1 over σ2. BD-1008 attenuates the toxicity and stimula...

CAS 139652-01-0 4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-

4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-
(CAS: 139652-01-0)

Sigma-LIGAND-1, also called as NPC 16377, is a selective sigma receptor ligand developed for the treatment of neurological disorders and psychotic disorders in ...

CAS 165377-44-6 SA-4503 dihydrochloride

SA-4503 dihydrochloride
(CAS: 165377-44-6)

SA-4503 is a potent sigma receptor agonist. SA-4503 may have effects on depressive symptoms such as agitation, loss of interest, and impaired cognition, which a...

CAS 75136-54-8 PRE-084 hydrochloride

PRE-084 hydrochloride
(CAS: 75136-54-8)

PRE-084 hydrochloride is a high affinity, selective receptors exhibiting neuroprotective effects. Its IC50 value is 44 nM in the sigma receptor assay. In vitro,...

CAS 154130-99-1 PD 144418 oxalate

PD 144418 oxalate
(CAS: 154130-99-1)

PD 144418 oxalate is a very selective sigma 1 agent (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively), devoid of any significant affinity for other re...

CAS 105565-55-7 BMY 14802 hydrochloride

BMY 14802 hydrochloride
(CAS: 105565-55-7)

BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with weak affinity for 5-HT1A and α1 receptors. BMY 14802 is potentially used as a...

CAS 172907-03-8 PB 28 dihydrochloride

PB 28 dihydrochloride
(CAS: 172907-03-8)

PB 28 dihydrochloride is a high affinity σ2 receptor agonist. It displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

CAS 75859-03-9 Rimcazole dihydrochloride

Rimcazole dihydrochloride
(CAS: 75859-03-9)

Rimcazole dihydrochloride is a small molecule antagonist of the σ-1 receptor (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively).

CAS 206996-13-6 BD1063 dhydrochloride

BD1063 dhydrochloride
(CAS: 206996-13-6)

BD1063 dhydrochloride is a potent and selective antagonist of sigma 1 receptor(Ki= 9.15 nM)with 50-fold more selective over sigma-2(Ki= 449 nM) and >100-fold mo...

CAS 149409-57-4 NE 100 hydrochloride

NE 100 hydrochloride
(CAS: 149409-57-4)

NE 100 hydrochloride is a σ1 receptor antagonist with IC50 value of 4.16 nM. It displays antipsychotic activity in vivo.

CAS 155054-42-5 N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide

(CAS: 155054-42-5)

N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide is a selective ligand belongs to benzamides, therapeutic agents for human prostate tumors sigma-1, which binds wit...

CAS 165377-43-5 Cutamesine

(CAS: 165377-43-5)

Cutamesine, also called as SA4503, is an agonist, small-molecule ligand for the sigma-1 receptor with high selectivity currently in development to mediate neuro...

CAS 359625-79-9 CYR-101

(CAS: 359625-79-9)

MIN-101, a novel cyclic amide derivative, is a 5-HT2A and sigma 2 receptor antagonist (Ki= 7.53 nM for 5-HT2A and 8.19 nM for sigma-2, respectively).

Chemical Structure

CAS 128-62-1 Noscapine

Quick Inquiry

Verification code

Featured Items