|Description||A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil. A potential antiplasmodial drug.|
BAY 73-6691 is a phosphodiesterase inhibitor selective for the PDE9A subtype under the development of Bayer. It selectively inhibits human PDE9 with IC50 value ...
Papaverine is an opiate alkaloid isolated from the plant Papaver somniferum. It is used primarily in the treatment of visceral spasm, vasospasm. It is also used...
Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic ag...
Bay 60-7550 is a potent PDE2 inhibitor. It is 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5 PDE3B, PDE4B...
Tadalafil binds to PDE5 with KD of 2.4 nM.
BRL 50481 is a potent, selective substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM).
A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil. A potential antiplasmodial drug.
PDE1-IN-1 is a potent PDE1 inhibitor and neuroprotective agent.
This active molecular is a Type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor originated by Chiesi Farmaceutici with IC50 value of 0.026 ± 0.006 nM. CH...
Vardenafil, also called as Levitra and Nuviva, is a phosphodiesterase inhibitor that is selective for PDE5 and PDE1 (IC50 = 0.7 and 180 nM, respectively).
Mirodenafil is a newly developed oral phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. It significantly improved ...
AWD 12-281 is a strong selective phosphodiesterase 4 (PDE4) inhibitor which has potent effects in models of lung inflammation using inhalative administration.
A phosphodiesterase inhibitor
Deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by Deltarasin suppresses proliferation of human pancr...
Sch59498 is a potent inhibitor of phosphodiesterase 1c (Pde1c) with antihypertensive and antiplatelet effect.
A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.
K134 is a selective phosphodiesterase 3 (PDE3) inhibitor, and has been shown to exhibit more potent anti-platelet activity than cilostazol. In vivo studies have...
Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barri...
LEO29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor. It shows properties suitable for patient-friendly formulations giving effic...
Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.