Nortadalafil - CAS 171596-36-4
Catalog number:
171596-36-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H17N3O4
Molecular Weight:
375.38
COA:
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Targets:
Phosphodiesterase (PDE)
Description:
A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil. A potential antiplasmodial drug.
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Purity:
>98%
Synonyms:
Demethyl Tadalafil
MSDS:
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1.Isolation and characterization of a tadalafil analogue, N-cyclopentyl nortadalafil in health supplement.
Xu Y1, Kee CL2, Ge X2, Low MY2, Koh HL3. J Pharm Biomed Anal. 2016 Jan 25;118:235-41. doi: 10.1016/j.jpba.2015.08.005. Epub 2015 Aug 6.
A tadalafil analogue was detected for the first time during the screening of a health supplement for undeclared sexual enhancement drugs. The compound had been isolated and purified by preparative high-pressure liquid chromatography (HPLC). Its chemical structure was elucidated using high-resolution mass spectrometry (HRMS), electrospray ionization tandem mass spectrometry (ESI-MS/MS) and nuclear magnetic resonance (NMR) spectroscopy. The compound had a protonated molecular ion at m/z 444 with a chemical formula of C26H25N3O4. The data obtained from the MS analysis of the compound suggested that the N-methyl group on the piperazinedione moiety of tadalafil was substituted with a -C5H9 group. Analysis using NMR was performed and the -C5H9 group was characterized as a cyclopentyl moiety. The analogue was named N-cyclopentyl nortadalafil.
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