Norfloxacin hydrochloride - CAS 68077-27-0
Catalog number:
68077-27-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H19ClFN3O3
Molecular Weight:
355.79
COA:
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Targets:
Antibacterial
Description:
Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division. It is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections.
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Purity:
>98%
Synonyms:
Noroxin hydrochloride; Chibroxin hydrochloride
MSDS:
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1.Antibiotic resistant Salmonella and Vibrio associated with farmed Litopenaeus vannamei.
Banerjee S1, Ooi MC, Shariff M, Khatoon H. ScientificWorldJournal. 2012;2012:130136. doi: 10.1100/2012/130136. Epub 2012 Apr 24.
Salmonella and Vibrio species were isolated and identified from Litopenaeus vannamei cultured in shrimp farms. Shrimp samples showed occurrence of 3.3% of Salmonella and 48.3% of Vibrio. The isolates were also screened for antibiotic resistance to oxolinic acid, sulphonamides, tetracycline, sulfamethoxazole/trimethoprim, norfloxacin, ampicillin, doxycycline hydrochloride, erythromycin, chloramphenicol, and nitrofurantoin. Salmonella enterica serovar Corvallis isolated from shrimp showed individual and multiple antibiotic resistance patterns. Five Vibrio species having individual and multiple antibiotic resistance were also identified. They were Vibrio cholerae (18.3%), V. mimicus (16.7%), V. parahaemolyticus (10%), V. vulnificus (6.7%), and V. alginolyticus (1.7%). Farm owners should be concerned about the presence of these pathogenic bacteria which also contributes to human health risk and should adopt best management practices for responsible aquaculture to ensure the quality of shrimp.
2.Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study.
Fischer HD1, Juurlink DN, Mamdani MM, Kopp A, Laupacis A. Arch Intern Med. 2010 Apr 12;170(7):617-21. doi: 10.1001/archinternmed.2010.37.
BACKGROUND: Some antibiotic agents, including cotrimoxazole, inhibit the metabolism of warfarin sodium and possibly increase the risk of hemorrhage. We examined the risk of upper gastrointestinal (UGI) tract hemorrhage in older patients receiving warfarin in combination with antibiotics commonly used to treat urinary tract infection, with a focus on cotrimoxazole.
3.[Isolation, identification and drug sensitivity of Streptococcus iniae from hybrid sturgeons (Huso dauricus female x Acipenser schrencki male)].
Wang X, Xu L, Wang J, Wang S, Cao H. Wei Sheng Wu Xue Bao. 2014 Apr 4;54(4):442-8.
OBJECTIVE: Sturgeons were the important economic species in Beijing. In July 2012, continuous mortality of cultured hybrid sturgeons was occurred on a farm in Huairou.
4.Development and validation of procedures for assessment of competency of non-pharmacists in extemporaneous dispensing.
Donnelly RF1, McNally MJ, Barry JG. Int J Pharm Pract. 2009 Feb;17(1):67-71.
OBJECTIVES: To develop and validate procedures that may be suitable for assessment of competency of two groups of non-pharmacist staff (pharmacy students and trainee support staff) in extemporaneous dispensing. This is important given the prospect of remote supervision of community pharmacies in the UK.
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CAS 68077-27-0 Norfloxacin hydrochloride

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