Norelgestromin - CAS 53016-31-2
Catalog number:
53016-31-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H29NO2
Molecular Weight:
327.465
COA:
Inquire
Targets:
Others
Description:
Norelgestromin is a metabolite of Norgestimate which is a steroidal progestin.
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Purity:
≥95%
Appearance:
White to Pae Yellow Solid
Synonyms:
17-Desacetyl norgestimate; (3E,8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A metabolite of Norgestimate.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
491.9ºC at 760mmHg
Melting Point:
107-109 ºC
Density:
1.23 g/cm3
InChIKey:
ISHXLNHNDMZNMC-VTKCIJPMSA-N
InChI:
1S/C21H29NO2/c1-3-20-11-9-17-16-8-6-15(22-24)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23-24H,3,5-12H2,1H3/b22-15+/t16-,17+,18+,19-,20-,21-/m0/s1
Canonical SMILES:
CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=NO)CCC34
1.The effect of rosuvastatin on oestrogen & progestin pharmacokinetics in healthy women taking an oral contraceptive.
Simonson SG1, Martin PD, Warwick MJ, Mitchell PD, Schneck DW. Br J Clin Pharmacol. 2004 Mar;57(3):279-86.
AIMS: To assess the effect of rosuvastatin on oestrogen and progestin pharmacokinetics in women taking a commonly prescribed combination oral contraceptive steroid (OCS); the effect on endogenous hormones and the lipid profile was also assessed.
2.UPLC-MS/MS assay for the simultaneous determination of ethinyl estradiol, norgestimate and 17-Desacetyl Huang MQ1, Kang L2, Wang W2, Skee D3, Chen M2, Lin ZJ2, Verhaeghe T4, Weng N5. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 1;1017-1018:1-9. doi: 10.1016/j.jchromb.2016.01.054. Epub 2016 Feb 23.
Previously, because of the difficulty of measuring very low levels (pg/mL) of norgestimate (NGM) due to rapid metabolism to its active and major metabolite, 17-Desacetyl norgestimate (DNGM), only DNGM and the co-administered ethinyl estradiol (EE2) were required to be analyzed in bioequivalence (BE) studies for oral contraceptive NGM/EE2 tablets. Recently, with more sensitive assays available, health authorities have requested that bioequivalence of NGM be also demonstrated in addition to DNGM and EE2. Therefore, it was important to establish a 3-in-1 method for the quantitation of EE2, NGM and DNGM in human plasma. Here a UPLC-MS/MS method for the simultaneous quantitation of EE2, NGM and DNGM in human plasma at low pg/mL range is described. EE2, NGM, DNGM and their isotopic labeled internal standards (IS) EE2-d4, NGM-d6 and DNGM-d6 in 0.4mL of human plasma were extracted with hexane/ethyl acetate. The extracts were evaporated to dryness and derivatized with dansyl chloride, to enhance the mass spec response.
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Chemical Structure

CAS 53016-31-2 Norelgestromin

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