NMS-P715 - CAS 1202055-32-0
Catalog number:
1202055-32-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C35H39F3N8O3
Molecular Weight:
676.73
COA:
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Targets:
Mps1
Description:
NMS-P715 was found to be highly specific for MPS1, with no other kinases inhibited below an IC50 value of 5 mmol/L and with only 3 kinases inhibited below 10 mmol/L (CK2, MELK, and NEK6), which were not significantly affected by compound preincubation. NMS-P715 promotes massive SAC override with a half-maximal effective concentration (EC50) of 65 nmol/L. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models.
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Purity:
>98%
Synonyms:
NMS P715; NMS-P 715
MSDS:
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