NMS-859 - CAS 1449236-96-7
Catalog number: 1449236-96-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H12ClN3O3S
Molecular Weight:
349.79
COA:
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Targets:
p97
Description:
NMS-859 is very selective (IC50 >10 μM) against all of the AAA ATPases, HSP90 or the 53 kinases tested. NMS-859 was active in a cell proliferation assay, with IC50 values of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively. NMS-859 covalently modifies VCP on the active site Cys522 and blocks ATP binding. NMS-859 provided critical validation of VCP as a cancer target, and it raises the possibility that targeting VCP might prevent proteasome inhibitor–resistant tumors from escaping through the aggresome-autophagy pathways and cause them to collapse under the high load of unfolded proteins.
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Purity:
>98%
Synonyms:
NMS-859
MSDS:
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CAS 1449236-96-7 NMS-859

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