|Description||NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors.|
LY 233536 is a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, but few detailed information has been published yet.
LY-221501, a piperidine derivative, has been found to be a NMDA receptor antagonist.
CGP 31358 is a compound that can bind to a site on the N-methyl-D-aspartate (NMDA) receptor which is coupled to both the transmitter recognition site and the ch...
L-701,324 is a selective antagonist at the glycine site of the NMDA glutamate receptor. L-701,324 shows a beneficial action in the animal model of parkinsonian ...
CGP 43487 has been found to be a NMDA receptor antagonist and was once studied about its influenment of dopaminergic function as a supplement in the treatment o...
TCN 237 dihydrochloride
TCN 237 dihydrochloride is a potent and NR2B-selective NMDA antagonist (Ki = 0.8 nM), blocks NR2B-mediated calcium influx in Ltk cells (Ki = 9.7 nM).
Besonprodil, a benzimidazolone bioisostere, is an NMDA antagonist that selective for the NR2B subunit.
Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neona...
AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotecti...
Eliprodil, a NR2B-NMDA receptor antagonist, was found to have neuroprotective activity in study of ischemia.
QNZ46, a NMDA receptor antagonist, has been studied to have potential effect in some neurological diseases for it works by influencing some amino acids combinat...
LY 235959 is a competitive N-Methyl-D-Aspartate Receptor antagonist originated by Eli Lilly. No development was reported for treatment of Movement disorders in ...
Dextromethorphan hydrobromide hydrate
Dextromethorphan, a dextratrorotatory morphinan, is a non-competitive, low affinity NMDA receptor antagonist.
Trofinetide is a NMDA antagonist under the development of Neuren Pharmaceuticals. It is an analogue of the neuropeptide (1-3) IGF-1, which is a simple tripeptid...
CIQ is a derivative of tetrahydroisoquinoline acts as subunit-selective potentiator of NMDA receptors containing the NR2C (EC50=2.7 μM) or NR2D (EC50=2.8 μM) su...
IC87201, an efficient inhibitor of PSD95-nNOS protein-protein interactions, was found by screening and shown to disrupt the nNOS/PSD-95 interaction in an in vit...
Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.
PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/...
(-)-MK 801 Maleate
MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.