NLG-919 - CAS 1402836-58-1
Catalog number:
B0084-462741
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H22N2O
Molecular Weight:
282.38
COA:
Inquire
Targets:
IDO
Description:
NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs).
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-462741 50 mg $199 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
An orally available inhibitor of IDO1, with potential immunomodulating and antineoplastic activities.
Purity:
> 98%
Appearance:
White solid
Synonyms:
GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078.
Solubility:
DMSO 15 mg/mL heating; Water < 1 mg/ml
Storage:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS:
Inquire
Quality Standard:
In-house
Shelf Life:
>2 years if stored properly
Quantity:
Grams-Kilos
Melting Point:
143 - 146°C
InChIKey:
YTRRAUACYORZLX-UHFFFAOYSA-N
InChI:
1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
Canonical SMILES:
C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related IDO Products


Benzomalvin C
(CAS: 157047-98-8)

A potent IDO inhibitor

CAS 1204669-37-3 IDO inhibitor 1

IDO inhibitor 1
(CAS: 1204669-37-3)

IDO-IN-5
(CAS: 1402837-79-9)

A potent human IDO inhibitor with IC50 of 1-10 μM.

CAS 1204669-58-8 Epacadostat

Epacadostat
(CAS: 1204669-58-8)

Epacadostat, also known as INCB024360 or INCB24360, is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM, with potential immunomodulating and a...

CAS 110117-83-4 Indoximod

Indoximod
(CAS: 110117-83-4)

A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essentia...

CAS 288-36-8 1H-1,2,3-triazole

1H-1,2,3-triazole
(CAS: 288-36-8)

A potent IDO inhibitor

IDO-IN-7
(CAS: 1402837-78-8)

A potent human IDO inhibitor with IC50 of <1 μM.

CAS 4707-32-8 β-Lapachone

β-Lapachone
(CAS: 4707-32-8)

β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae), exhibiting anti-inflammatory properties by suppr...

IDO-IN-1
(CAS: 914638-30-5)

An IDO inhibitor with IC50 of 59 nM, shows activity in Hela cell (IC50=12 nM).

CAS 1402836-58-1 NLG-919

NLG-919
(CAS: 1402836-58-1)

NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tr...

CAS 914471-09-3 INCB024360-analog

INCB024360-analog
(CAS: 914471-09-3)

Potent competitive inhibitor of IDO1 with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; This INCB024360-analog decreased kynurenine l...

IDO-IN-6
(CAS: 1402837-76-6)

A potent human IDO inhibitor with IC50 of <1 μM.

CAS 538-28-3 2-Benzyl-2-thiopseudourea hydrochloride

2-Benzyl-2-thiopseudourea hydrochloride
(CAS: 538-28-3)

A potent IDO inhibitor

CAS 7259-44-1 Norharmane hydrochloride

Norharmane hydrochloride
(CAS: 7259-44-1)

A potent IDO inhibitor

IDO-IN-4
(CAS: 1629125-65-0)

A potent IDO1 inhibitor with IC50 of 8 nM in human IDO1/HEK293 cells.

CAS 615-21-4 2-hydrazinobenzothiazole

2-hydrazinobenzothiazole
(CAS: 615-21-4)

A potent IDO inhibitor

IDO-IN-3

A potent IDO inhibitor.

annulin B
(CAS: 1346859-52-6)

A potent IDO inhibitor

Halicloic acid A
(CAS: 1393581-27-5)

A potent IDO inhibitor

CAS 144060-53-7 Febuxostat

Febuxostat
(CAS: 144060-53-7)

A potent IDO inhibitor

Chemical Structure

CAS 1402836-58-1 NLG-919

Quick Inquiry

Verification code

Featured Items