Nizatidine - CAS 76963-41-2
Catalog number: 76963-41-2
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Histamine Receptor
Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.
Nizatidine, LY-139037, Tazac, Axid, LY 139037, LY139037; DL-Octopamine hydrochloride
Canonical SMILES:
1.Gastrointestinal dysmotility disorders in critically ill dogs and cats.
Whitehead K1, Cortes Y1, Eirmann L2. J Vet Emerg Crit Care (San Antonio). 2016 Mar;26(2):234-53. doi: 10.1111/vec.12449. Epub 2016 Jan 28.
OBJECTIVE: To review the human and veterinary literature regarding gastrointestinal (GI) dysmotility disorders in respect to pathogenesis, patient risk factors, and treatment options in critically ill dogs and cats.
2.The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson's disease.
Barboza JL1, Okun MS2, Moshiree B3. Expert Opin Pharmacother. 2015;16(16):2449-64. doi: 10.1517/14656566.2015.1086747. Epub 2015 Sep 16.
INTRODUCTION: Parkinson's disease (PD) affects the nerves of the entire gastrointestinal (GI) tract and may result in profound gastrointestinal (GI) dysfunction leading to poor patient outcomes. Common GI disturbances in patients with PD include gastroparesis (GP), constipation and small intestinal bacterial overgrowth syndrome (SIBO). In particular, GP is difficult to treat due to the limited options available and precautions, contraindications and adverse effects associated with the approved treatments. Moreover, some commonly used medications can worsen pre-existing PD.
3.Histamine-2 Receptor Antagonists and Semen Quality.
Banihani SA1. Basic Clin Pharmacol Toxicol. 2016 Jan;118(1):9-13. doi: 10.1111/bcpt.12446. Epub 2015 Aug 6.
Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer and gastro-oesophageal reflux disease. Although such drugs, especially ranitidine and famotidine, are still widely used, their effects on semen quality, and hence on male infertility, is still unclear. This MiniReview systematically addresses and summarizes the effect of histamine-2 receptor antagonists (cimetidine, ranitidine, nizatidine and famotidine) on semen quality, particularly, on sperm function. Cimetidine appears to have adverse effects on semen quality. While the effects of ranitidine and nizatidine on semen quality are still controversial, famotidine does not appear to change semen quality. Therefore, additional studies will be required to clarify whether histamine-2 receptor-independent effects of these drugs play a role in semen quality as well as further clinical studies including direct comparison of the histamine-2 receptor antagonists.
4.The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.
Morrissey KM1,2, Stocker SL1,3, Chen EC1,4, Castro RA1, Brett CM5, Giacomini KM6. Clin Pharmacokinet. 2016 Apr;55(4):495-506. doi: 10.1007/s40262-015-0332-9.
BACKGROUND AND OBJECTIVES: In the proximal tubule, basic drugs are transported from the renal cells to the tubule lumen through the concerted action of the H(+)/organic cation antiporters, multidrug and toxin extrusion (MATE) 1 and MATE2K. Dual inhibitors of the MATE transporters have been shown to have a clinically relevant effect on the pharmacokinetics of concomitantly administered basic drugs. However, the clinical impact of selective renal organic cation transport inhibition on the pharmacokinetics and pharmacodynamics of basic drugs, such as metformin, is unknown. This study sought to identify a selective MATE2K inhibitor in vitro and to determine its clinical impact on the pharmacokinetics and pharmacodynamics of metformin in healthy subjects.
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CAS 76963-41-2 Nizatidine

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