Nitroxoline - CAS 4008-48-4
Catalog number:
4008-48-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H6N2O3
Molecular Weight:
190.16
COA:
Inquire
Targets:
Antibacterial
Description:
Nitroxoline is a urinary antibacterial agent had proven to be very effective at combating biofilm infections.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥95%
Appearance:
Ochre-yellow to brownish crystalline powder
Synonyms:
8-Hydroxy-5-nitroquinoline;
Solubility:
Soluble in DMSO
Storage:
Store at 2-8 °C
MSDS:
Inquire
Application:
An antibiotic
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
419ºC at 760mmHg
Melting Point:
181-183 ºC
Density:
1.496
InChIKey:
RJIWZDNTCBHXAL-UHFFFAOYSA-N
InChI:
1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
Canonical SMILES:
C1=CC2=C(C=CC(=C2N=C1)O)[N+](=O)[O-]
1.The syntheses and structures of '3+2' and '2+2+1' oxorhenium mixed-ligand complexes employing 8-hydroxy-5-nitroquinoline as the bidentate N,O donor ligand.
Chen X1, Femia FJ, Babich JW, Zubieta J. Inorganica Chim Acta. 2000 Oct 20;308(1-2):80-90.
The syntheses and structural characterizations of a series of novel '3+2' and '2+2+1' mixed-ligand complexes carrying 8-hydroxy-5-nitroquinoline (HL) as the bidentate N,O donor atom system are reported. Thus one-pot reactions of [ReOCl(3)(PPh(3))(2)] with dianionic tridentate ligands H(2)L(n) (where H(2)L(1)=HOC(6)H(4)-2-CH=NC(6)H(4)-2-OH; H(2)L(2)=HOC(6)H(4)-2-CH=N-C(6)H(4)-2-SH; H(2)L(3)=HOC(6)H(4)-2-CH=NN=C(NHC(6)H(5))-SH; H(2)L(4)=2-CH(2)OH-C(5)H(3)N-6-CH(2)SH; and H(2)L(5)=2-CO(2)H-C(5)H(3)N-6-CO(2)H) and HL afforded a series of '3+2' oxorhenium complexes of the type [ReO(H(2)L(n))(L)] 2-6, which exhibit distorted octahedral geometries. Crystals of 1 are monoclinic space group C2/c, a=16.702(1), b=14.275(1), c=22.363(2) A, beta=108.083(1) degrees V=5068.2(7) A(beta) and Z=8; those of 2 are monoclinic space group P2(1)/n, a=8.5093(4) b=38.518(2), c=11.6092(5) A, beta=97.708(1) degrees , V=3770.7(3) A(3) and Z=8; those of 5 are triclinic, space group P1-, a=7.
2.Powder diffraction study of the hydrogen bonds in nitroxoline and its hydrochloride.
Yatsenko AV1, Paseshnichenko KA, Chernyshev VV, Schenk H. Acta Crystallogr C. 2002 Jan;58(Pt 1):o19-21. Epub 2001 Dec 14.
The crystal structures of 8-hydroxy-5-nitroquinoline, C9H6N2O3, (I), and 8-hydroxy-5-nitroquinolinium chloride, C9H7N2O3+*Cl-, (II), have been determined from X-ray powder data. In (I), the molecules are linked via moderately strong hydrogen bonds to form dimers. Such a packing motif is likely to be responsible for the low solubility of (I) in water. In (II), the inversion-related cations form stacks, and anions fill the interstack channels.
3.[Present status of nitroxoline].
Bergogne-Berezin E1, Berthelot G, Muller-Serieys C. Pathol Biol (Paris). 1987 Jun;35(5 Pt 2):873-8.
Nitroxoline (8-hydroxy-5-nitroquinoline) has been used since 1962 in the treatment of urinary tract infections especially those due to gram negative bacilli (E. coli). The current renewal of the drug is in relation to the recently shown activity of nitroxoline against fungi (Candida, Torulopsis), Mycoplasma and U. urealyticum, as well as Trichomonas. In order to update the knowledge of the drug, the aim of this study was a pharmacokinetic study in serum and urines collected after administration of one single dose (2 X 100 mg) and after multiple doses (200 mg X 3). Eight healthy volunteers were included in the study. The assays were carried out by means of the microbiological procedure and HPLC comparatively in the same samples. From the results several comments should be made: 1) In all subjects, serum levels were measurable 15 to 30 min. after administration, suggesting a rapid absorption. 2) Despite individual variations due to oral administration, pharmacokinetic parameters could be calculated: Tmax: 1.
4.Experimental and theoretical quantum chemical investigations of 8-hydroxy-5-nitroquinoline.
Arjunan V1, Balamourougane PS, Kalaivani M, Raj A, Mohan S. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Oct;96:506-16. doi: 10.1016/j.saa.2012.05.080. Epub 2012 Jun 6.
The FT-IR and FT-Raman spectra of 8-hydroxy-5-nitroquinoline have been recorded in the regions 4000-400 and 4000-100 cm(-1), respectively. The spectra were interpreted in terms of fundamentals modes, combination and overtone bands. The normal coordinate analysis was carried out to confirm the precision of the assignments. The structure of the compound was optimised and the structural characteristics were determined by density functional theory (DFT) using B3LYP method with 6-31G(**), 6-311++G(**) and cc-pVDZ basis sets. The vibrational frequencies were calculated in all these methods and were compared with the experimental frequencies which yield good agreement between observed and calculated frequencies. The infrared and Raman spectra were also predicted from the calculated intensities. (1)H and (13)C NMR spectra were recorded and (1)H and (13)C nuclear magnetic resonance chemical shifts of the molecule were calculated using the gauge independent atomic orbital (GIAO) method.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


Vaborbactam
(CAS: 1360457-46-0)

Vaborbactam is a selective beta-lactamase inhibitor under the development of Rempex Pharmaceuticals. Vaborbactam is a broad-spectrum inhibitor, especially resto...

CAS 72559-06-9 Rifabutin

Rifabutin
(CAS: 72559-06-9)

Rifabutin inhibits bacterial RNA polymerase.

CAS 1695-77-8 Spectinomycin

Spectinomycin
(CAS: 1695-77-8)

Spectinomycin, a derivative of streptomyces spectabilis, has been found to be effective against gram-negative bacteria.

CAS 888032-58-4 WQ3810

WQ3810
(CAS: 888032-58-4)

WQ3810 is a newly developed fluoroquinolone withunique substituents at the N1 and C7 positions of the quinolone ringfor the treatment of antibiotic-resistant in...

CAS 80621-81-4 Rifaximin

Rifaximin
(CAS: 80621-81-4)

Rifaximin, an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity.

CAS 5854-93-3 Alanosine

Alanosine
(CAS: 5854-93-3)

Alanosine, also known as L-alanosine, is an antitumor antibiotic substance from the fermentation of Streptomyces alanosinicus. L-Alanosine inhibits adenylosucci...

CAS 52794-97-5 Carubicin HCl

Carubicin HCl
(CAS: 52794-97-5)

Carubicin HCl, isolated from the bacterium Actinomadura carminata, is a very toxic anthracycline-type, antineoplastic antibiotic.

Ribocil-C
(CAS: 1825355-56-3)

Ribocil-C is a more active analog of ribocil. Ribocil is a potent and highly selective synthetic mimic of FMN and inhibit bacterial growth both in vitro and in ...

CAS 13159-28-9 Betulinaldehyde

Betulinaldehyde
(CAS: 13159-28-9)

Betulinaldehyde(Betunal) belongs to pentacyclic triterpenoids that are based on a 30-carbon skeleton comprising four six-membered rings and one five-membered ri...

CAS 153-61-7 Cephalothin

Cephalothin
(CAS: 153-61-7)

Cephalothin, one of the first generation cephalosporin antibiotic, has been found to be probably effective in some respiratory diseases and neuromuscular juncti...

CAS 127-56-0 Sulfacetamide Sodium

Sulfacetamide Sodium
(CAS: 127-56-0)

Sulfacetamide Sodium is an anti-biotic.

CAS 112811-59-3 Gatifloxacin

Gatifloxacin
(CAS: 112811-59-3)

Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

CAS 68077-27-0 Norfloxacin hydrochloride

Norfloxacin hydrochloride
(CAS: 68077-27-0)

Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA...

CAS 57018-04-9 Tolclofos-Methyl

Tolclofos-Methyl
(CAS: 57018-04-9)

Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide as an excellent foundation seed fungicide.

CAS 68401-82-1 Ceftizoxime sodium

Ceftizoxime sodium
(CAS: 68401-82-1)

A semisynthetic cephalosporin antibiotic for the treatment of infections due to susceptible strains of microorganisms.

CAS 34444-01-4 Cefamandole

Cefamandole
(CAS: 34444-01-4)

Cefamandole is is the formate ester cefamandole nafate, a second-generation broad-spectrum cephalosporin antibiotic. It releases free NMTT, which can cause hypo...

CAS 74-55-5 Ethambutol

Ethambutol
(CAS: 74-55-5)

Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. lt directly affects tw...

CAS 100986-85-4 Levofloxacin

Levofloxacin
(CAS: 100986-85-4)

Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achiev...

CAS 856866-72-3 Tedizolid

Tedizolid
(CAS: 856866-72-3)

Torezolid is a novel oxazolidinone for gram-positive infections. It was reversible inhibitors of human MAO-A and MAO-B.

CAS 859-18-7 Lincomycin HCl

Lincomycin HCl
(CAS: 859-18-7)

Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis.

Chemical Structure

CAS 4008-48-4 Nitroxoline

Quick Inquiry

Verification code

Featured Items