1. Efﬁcacy of an experimental fasciolicide against immature and mature Fasciola hepatica in artiﬁcially infected calves
Y. Vera Montenegro, F. Ibarra Velarde, E. Liebano Hernandez, H. Quiroz Romero. Parasitol Res (2004) 92: 211–214
More recently, Ibarra et al. (2001) have observed that TCB showed lower fasciolicide activity (71.7%) against immature stages of F. hepatica when tested at recommended doses in cattle naturally infected with the trematode. In our study, compound alpha showed higher activity against ﬂukes aged 4 and 6 weeks. In another study Vera et al. (2003) determined the per- centage of ﬂuke egg reduction in naturally infected cattle, obtaining a 97% eﬃcacy at the dose rate of 12 mg/kg by mouth. It is also important to note that compound alpha overcomes the problem of lack of activity shown against immature stages by older fasciolicides such as meniclofolan, nitroxinil, rafoxanide, albendazole, closantel and clorsulon, among others (Cordero del Campillo and Rojo Vazquez 1999).