Nimorazole - CAS 6506-37-2
Catalog number:
6506-37-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H14N4O3
Molecular Weight:
226.23
COA:
Inquire
Targets:
Antiparasitic
Description:
Nimorazole is a nitroimidazole anti-infective. It significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be given without major side-effects. It is also the only such agent to have shown a significant effect in a randomized controlled trial in head and neck cancer.
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Purity:
>98%
Synonyms:
Nitrimidazine; Naxogin
MSDS:
Inquire
1.Clinical implications of hypoxia biomarker expression in head and neck squamous cell carcinoma: a systematic review.
Swartz JE1, Pothen AJ1, Stegeman I1,2, Willems SM3, Grolman W1,2. Cancer Med. 2015 Jul;4(7):1101-16. doi: 10.1002/cam4.460. Epub 2015 Apr 27.
Awareness increases that the tumor biology influences treatment outcome and prognosis in cancer. Tumor hypoxia is thought to decrease sensitivity to radiotherapy and some forms of chemotherapy. Presence of hypoxia may be assessed by investigating expression of endogenous markers of hypoxia (EMH) using immunohistochemistry (IHC). In this systematic review we investigated the effect of EMH expression on local control and survival according to treatment modality in head and neck cancer (head and neck squamous cell carcinoma [HNSCC]). A search was performed in MEDLINE and EMBASE. Studies were eligible for inclusion that described EMH expression in relation to outcome in HNSCC patients. Quality was assessed using the Quality in Prognosis Studies (QUIPS) tool. Hazard ratios for locoregional control and survival were extracted. Forty studies of adequate quality were included. HIF-1a, HIF-2a, CA-IX, GLUT-1, and OPN were identified as the best described EMHs.
2.A rapid and sensitive determination of hypoxic radiosensitizer agent nimorazole in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
Das S1, Dubey R1, Roychowdhury S1, Ghosh M1, Sinha BN1, Kumar Pradhan K1, Bal T1, Muthukrishnan V2, Seijas JA3, Pujarid A4. Biomed Chromatogr. 2015 Oct;29(10):1575-80. doi: 10.1002/bmc.3461. Epub 2015 Apr 5.
A highly sensitive, accurate and robust LC-MS/MS method was developed and validated for determination of nimorazole (NMZ) in rat plasma using metronidazole (MNZ) as internal standard (IS). The analyte and IS were extracted from plasma by precipitating protein with acetonitrile and were chromatographed using an Agilent Poroshell 120, EC-C18 column. The mobile phase was composed of a mixture of acetonitrile and 0.1 % formic acid (85:15 v/v). The total run time was 1.5 min and injection volume was 5 μL. Multiple reaction monitoring mode using the transitions of m/z 227.1 → m/z 114.0 for MNZ and m/z 172.10 → m/z 128.1 for IS were monitored on a triple quadrupole mass spectrometer, operating in positive ion mode. The calibration curve was linear in the range of 0.25-200 ng/mL (r(2)  > 0.9996) and the lower limit of quantification was 0.25 ng/mL in the rat plasma samples. Recoveries of NMZ ranged between 88.05 and 95.25%. The precision (intra-day and inter-day) and accuracy of the quality control samples were 1.
3.Locally advanced head and neck cancer treated with accelerated radiotherapy, the hypoxic modifier nimorazole and weekly cisplatin. Results from the DAHANCA 18 phase II study.
Bentzen J1, Toustrup K, Eriksen JG, Primdahl H, Andersen LJ, Overgaard J. Acta Oncol. 2015 Jul;54(7):1001-7. doi: 10.3109/0284186X.2014.992547. Epub 2015 Jan 28.
PURPOSE/OBJECTIVE: A phase II clinical trial evaluating the feasibility and outcome of treating locally advanced head and neck squamous cell carcinoma (HNSCC) with accelerated radiotherapy, the hypoxic modifier nimorazole and weekly cisplatin.
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CAS 6506-37-2 Nimorazole

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