Niflumic Acid - CAS 4394-00-7
Catalog number: 4394-00-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C13H9F3N2O2
Molecular Weight:
282.2
COA:
Inquire
Targets:
Cox-2 | Others
Description:
A selective COX-2 inhibitor; GPR35 activator; Cox-2: IC50 = 918 nM (human); Cox-1: IC50 = 1.06 µM (human); GPR35: IC50 = 1.28 µM (human)
Brife Description:
A selective COX-2 inhibitor; GPR35 activator; Cox-2: IC50 = 918 nM (human); Cox-1: IC50 = 1.06 µM (human); GPR35: IC50 = 1.28 µM (human)
Appearance:
A crystalline solid
Synonyms:
2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid; Actol; Donalgin; Nifluril; UP83
Solubility:
Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25° C), and acetonitrile (~50 mg/ml)
Storage:
Store at room temperature
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Boiling Point:
~378.0° C at 760 mmHg (Predicted)
Melting Point:
203-204° C
InChIKey:
JZFPYUNJRRFVQU-UHFFFAOYSA-N
InChI:
1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
Canonical SMILES:
OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F
1.Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel.
Sato-Numata K1,2,3, Numata T2, Inoue R2, Okada Y4,5. Pflugers Arch. 2016 May;468(5):795-803. doi: 10.1007/s00424-015-1786-1. Epub 2016 Jan 8.
Expressed by many cell types, acid-sensitive outwardly rectifying (ASOR) anion channels are known to be activated by extracellular acidification and involved in acidotoxic necrotic cell death. In contrast, ubiquitously expressed volume-sensitive outwardly rectifying (VSOR) anion channels are activated by osmotic cell swelling and involved in cell volume regulation and apoptotic cell death. Distinct inhibitors to distinguish ASOR from VSOR anion channels have not been identified. Although leucine-rich repeats containing 8A (LRRC8A) was recently found to be an essential component of VSOR anion channels, the possibility of an LRRC8 family member serving as a component of ASOR anion channels has not been examined. In this study, we explored the effects of 12 known VSOR channel inhibitors and small interfering RNA (siRNA)-mediated knockdown of LRRC8 family members on ASOR and VSOR currents in HeLa cells. Among these inhibitors, eight putative VSOR blockers, including 4-(2-butyl-6,7-dichlor-2-cyclopentylindan-1-on-5-yl) oxobutyric acid (DCPIB) and 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB), were totally ineffective at blocking ASOR channel activity, whereas suramin, R-(+)-[(2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy] acetic acid (DIOA), arachidonic acid, and niflumic acid were found to be effective ASOR anion channel antagonists.
2.Niflumic acid exhibits anti-tumor activity in nasopharyngeal carcinoma cells through affecting the expression of ERK1/2 and the activity of MMP2 and MMP9.
Luo S1, Huang G1, Wang Z1, Wan Z1, Chen H1, Liao D1, Chen C1, Li H1, Li B1, Chen L1, Huang Z1, He Z1. Int J Clin Exp Pathol. 2015 Sep 1;8(9):9990-10001. eCollection 2015.
Niflumic acid (NFA) was known to inhibit cell proliferation or migration in several types of cancer. However, the function of NFA in human nasopharyngeal carcinoma (NPC) cells was not clarified. The proliferation of NPC cell line CNE-2Z cells with NFA treatment was detected using the cell counting kit-8 method and transwell assay was employed to assess the effect of NFA on the CNE-2Z cell migration and invasion. The activity of MMP2 and MMP9 was detected by Gelatin Zymography. Cell cycle distribution and apoptosis were detected using flow cytometry. In vitro pull-down assay, western blot, and computational technique were applied to investigate the NFA regulating signaling pathway. Our results indicated that the growth capacity and colony formation potential of CNE-2Z cells in soft agar were significantly suppressed by treatment with NFA. NFA inhibited the proliferation of CNE-2Z cells in a concentration and time-dependent manner. NFA exerted an S phase arrest on the CNE-2Z cells in a concentration-dependent manner, while promoting apoptosis in a dose-dependent manner.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Cox-2 Products


N-(4-acetamidophenyl)-Indomethacin amide
(CAS: 261766-23-8)

An elective reversible inhibitors of COX-2

CAS 103-90-2 Acetaminophen

Acetaminophen
(CAS: 103-90-2)

A selective COX-2 inhibitor

CAS 41340-25-4 Etodolac

Etodolac
(CAS: 41340-25-4)

A non-selective inhibitor of COX

CAS 15307-86-5 Diclofenac

Diclofenac
(CAS: 15307-86-5)

A non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.

SI-2 hydrochloride

SI-2 hydrochloride is a potent and orally available steroid receptor coactivator 3 (SRC-3) inhibitor. SI-2 has been shown to decrease SRC1, SRC2 and SRC3 levels...

FR-168888 Free Base
(CAS: 168620-45-9)

The free base of FR-168888, a guanidine compound, has been found to be a sodium hydrogen antiporter inhibitor that was once studied in myocardial ischaemia ther...

CAS 170569-86-5 SC-236

SC-236
(CAS: 170569-86-5)

A potent, selective COX-2 inhibitor

CAS 160162-42-5 SR 11302

SR 11302
(CAS: 160162-42-5)

SR 11302 is an inhibitor of activator protein-1 (AP-1), which is a transcription factor activity that displays antitumor effects in vivo. SR 11302 does not acti...

Chemical Structure

CAS 4394-00-7 Niflumic Acid

Quick Inquiry

Verification code

Featured Items