Nicotinic Acid - CAS 59-67-6
Catalog number: 59-67-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Nicotinic Acid is a water-soluble vitamin belonging to the vitamin B family.
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1.Nicotinic acid supplementation in diet favored intramuscular fat deposition and lipid metabolism in finishing steers.
Yang ZQ1, Bao LB1, Zhao XH1, Wang CY1, Zhou S1, Wen LH1, Fu CB1, Gong JM1, Qu MR2. Exp Biol Med (Maywood). 2016 Apr 4. pii: 1535370216639395. [Epub ahead of print]
Nicotinic acid (NA) acting as the precursor of NAD+/NADH and NADP+/NADPH, participates in many biochemical processes, e.g. lipid metabolism. The main purpose of this study was to investigate the effects of dietary NA on carcass traits, meat quality, blood metabolites, and fat deposition in Chinese crossbred finishing steers. Sixteen steers with the similar body weight and at the age of 24 months were randomly allocated into control group (feeding basal diet) and NA group (feeding basal diet + 1000 mg/kg NA). All experimental cattle were fed a 90% concentrate diet and 10% forage straw in a 120-day feeding experiment. The results showed that supplemental NA in diet increased longissimus area, intramuscular fat content (17.14% vs. 9.03%), marbling score (8.08 vs. 4.30), redness (a*), and chroma (C*) values of LD muscle, but reduced carcass fat content (not including imtramuscular fat), pH24 hand moisture content of LD muscle, along with no effect on backfat thickness.
2.Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.
Trammell SA1, Yu L2, Redpath P3, Migaud ME4, Brenner C5. J Nutr. 2016 Apr 6. pii: jn230078. [Epub ahead of print]
BACKGROUND: Nicotinamide riboside (NR) is a recently discovered NAD+precursor vitamin with a unique biosynthetic pathway. Although the presence of NR in cow milk has been known for more than a decade, the concentration of NR with respect to the other NAD+precursors was unknown.
3.Pharmacological effects of niacin on acute hyperlipemia.
Montserrat-de la Paz S1, Bermudez B, Carmen Naranjo M, Lopez S, Abia R, Muriana FJ. Curr Med Chem. 2016 Apr 11. [Epub ahead of print]
The well-known changes in modern lifestyle habits including over nutrition and physical inactivity have led to striking adverse effects on public health (e.g., obesity, diabetes, and metabolic syndrome) over recent decades. One noticeable consequence is exaggerated and prolonged states of postprandial hyperlipemia due to the ingestion of multiple fat-enriched meals during the course of a day. Postprandial (non-fasting) hyperlipemia is characterized by increased blood levels of exogenous triglycerides (TG) in the form of apolipoprotein (apo) B48-containing TG-rich lipoproteins (TRL), which have a causal role in the pathogenesis and progression of cardiovascular disease (CVD). The cardiovascular benefits of lifestyle modification (healthy diet and exercise) and conventional lipid-lowering therapies (e.g., statins, fibrates, and niacin) could involve their favourable effects on postprandial metabolism. Pharmacologically, niacin has been used as an athero-protective drug for five decades.
4.Ca2+ dialogue between acidic vesicles and ER.
Morgan AJ1. Biochem Soc Trans. 2016 Apr 15;44(2):546-53. doi: 10.1042/BST20150290.
Extracellular stimuli evoke the synthesis of intracellular second messengers, several of which couple to the release of Ca(2+)from Ca(2+)-storing organelles via activation of cognate organellar Ca(2+)-channel complexes. The archetype is the inositol 1,4,5-trisphosphate (IP3) and IP3receptor (IP3R) on the endoplasmic reticulum (ER). A less understood, parallel Ca(2+)signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca(2+)release from acidic Ca(2+)stores [e.g. endo-lysosomes, secretory vesicles, lysosome-related organelles (LROs)]. NAADP-induced Ca(2+)release absolutely requires organellar TPCs (two-pore channels). This review discusses how ER and acidic Ca(2+)stores physically and functionally interact to generate and shape global and local Ca(2+)signals, with particular emphasis on the two-way dialogue between these two organelles.
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CAS 59-67-6 Nicotinic Acid

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