Nicorandil - CAS 65141-46-0
Catalog number:
Not Intended for Therapeutic Use. For research use only.
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Molecular Weight:
Potassium Channel
Nicorandil is potassium channel activator.
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1.Nicorandil attenuates carotid intimal hyperplasia after balloon catheter injury in diabetic rats.
Zhang YQ1, Tian F1, Zhou Y1, Chen YD2, Li B1, Ma Q1, Zhang Y1. Cardiovasc Diabetol. 2016 Apr 8;15(1):62. doi: 10.1186/s12933-016-0377-6.
BACKGROUND: Diabetic patients suffer from undesired intimal hyperplasia after angioplasty. Nicorandil has a trend to reduce the rate of target lesion revascularization. However, whether nicorandil inhibits intimal hyperplasia and the possible mechanisms underlying it remain to be determined. We aimed at assessing the effect of nicorandil on intimal hyperplasia in diabetic rats.
2.Impact of additional intracoronary nicorandil administration during fractional flow reserve measurement with intravenous adenosine 5'-triphosphate infusion.
Takami H1, Sonoda S2, Muraoka Y1, Sanuki Y1, Kashiyama K1, Fukuda S1, Oginosawa Y1, Tsuda Y1, Araki M1, Otsuji Y1. J Cardiol. 2016 Feb 29. pii: S0914-5087(16)00029-0. doi: 10.1016/j.jjcc.2016.01.018. [Epub ahead of print]
BACKGROUND: Fractional flow reserve (FFR) is a useful index for determining the functional severity of epicardial coronary artery stenosis as an invasive physiological method. Although intravenous adenosine 5'-triphosphate (ATP) is generally used as a hyperemic agent for FFR measurement in Japan, there are some concerns about the variability of FFR measurement (short half-life, effect of caffeine, cyclic change). It is difficult to confirm sufficient maximum hyperemia after ATP infusion. Recent studies reported that nicorandil (NIC) could be an alternative to ATP as a hyperemic agent.
3.Nicorandil Inhibits Cyclic Strain-Induced Interleukin-8 Expression in Human Umbilical Vein Endothelial Cells.
Chao HH1, Hong HJ, Cheng TH, Shih NL, Loh SH, Liu JC, Chen JJ, Sung LC. Pharmacology. 2016 Apr 7;98(1-2):42-50. [Epub ahead of print]
BACKGROUND: Nicorandil, a mitochondrial adenosine triphosphate-sensitive potassium (mitoKATP) channel opener, exerts protective effects on the cardiovascular system. This study examined the effect of nicorandil on cyclic strain-induced interleukin-8 (IL-8) expression in human umbilical vein endothelial cells (HUVECs).
4.Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation.
Dong YF1,2, Chen ZZ3, Zhao Z4, Yang DD5, Yan H6, Ji J7, Sun XL8. J Neuroinflammation. 2016 Mar 9;13(1):60. doi: 10.1186/s12974-016-0527-5.
BACKGROUND: It is generally recognized that the inflammatory reaction in glia is one of the important pathological factors in brain ischemic injury. Our previous study has revealed that opening ATP-sensitive potassium (K-ATP) channels could attenuate glial inflammation induced by ischemic stroke. However, the detailed mechanisms are not well known.
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CAS 65141-46-0 Nicorandil

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