Nicardipine Hydrochloride - CAS 54527-84-3
Catalog number:
54527-84-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H29N3O6.HCl
Molecular Weight:
515.99
COA:
Inquire
Targets:
Calcium Channel
Description:
Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
RS-69216
MSDS:
Inquire
1.Pre-surgical regional blocks in orthognathic surgery: prospective study evaluating their influence on the intraoperative use of anaesthetics and blood pressure control.
Chen YA1, Rivera-Serrano CM1, Chen C2, Chen YR3. Int J Oral Maxillofac Surg. 2016 Jan 19. pii: S0901-5027(15)01332-6. doi: 10.1016/j.ijom.2015.09.014. [Epub ahead of print]
In orthognathic surgery, maxillary (CNV2) and mandibular (CNV3) divisions of the trigeminal nerve can be blocked successfully prior to surgery. In this study, it was hypothesized that regional blocks (nerve block over a particular region: bilateral CNV2 and CNV3 divisions of the trigeminal nerve) would decrease the total requirement for intraoperative anaesthetic agents and facilitate the process of hypotensive anaesthesia. Local anaesthesia containing 1/100,000 epinephrine and 10ml 0.5% levobupivacaine was injected into the planned incisions in 50 patients. Twenty-five patients (group A) underwent orthognathic surgery without regional blocks and another 25 patients (group B) underwent surgery with regional blocks. The anaesthetic protocol was the same in both groups and administered by a single anaesthesiologist. The mean arterial pressure was recorded at several points throughout the operation, as well as all the medications used. The blood loss and the amounts of medications administered were lower in group B than in group A.
2.Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study.
Wang YC1, Hsieh TC, Chou CL, Wu JL, Fang TC. Medicine (Baltimore). 2016 Jan;95(2):e2487. doi: 10.1097/MD.0000000000002487.
Some statins (simvastatin, lovastatin, and atorvastatin) are metabolized by cytochrome P450s 3A4 (CYP3A4). Inhibitors of CYP3A4 including some calcium channel blockers (CCBs) might increase statin blood concentration, owing to drug-drug interactions. Risk of adverse events such as acute kidney injury might occur following the coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4.This was a population-based cohort study. The study analyzed data of patients treated between 1997 and 2011, retrieved from Taiwan's National Health Insurance database. We enrolled 32,801 patients who received coprescription of statins and CCBs that inhibit CYP3A4 (amlodipine, diltiazem, felodipine nicardipine, nifedipine, and verapamil). These patients were divided into 2 groups, according to whether they had received CYP3A4-metabolized statins (lovastatin, simvastatin, and atorvastatin) or non-CYP3A4-metabolized statins (fluvastatin, rosuvastatin, and pitavastatin).
3.Nicardipine for Hypertension Following Aortic Coarctectomy or Superior Cavopulmonary Anastomosis.
Mastropietro CW1, Arango Uribe D2. World J Pediatr Congenit Heart Surg. 2016 Jan;7(1):32-5. doi: 10.1177/2150135115608815.
BACKGROUND: Literature on the use of nicardipine, a dihydropyridine calcium channel antagonist, in children recovering from cardiac surgery is sparse and, to our knowledge, nonexistent in children with single ventricle anatomy. We aimed to report our experience with nicardipine in these patient populations.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Calcium Channel Products


PD 122860
(CAS: 122576-86-7)

This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...

CAS 478296-72-9 Gabapentin enacarbil

Gabapentin enacarbil
(CAS: 478296-72-9)

Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin.

CAS 111011-63-3 EFONIDIPINE

EFONIDIPINE
(CAS: 111011-63-3)

Efonidipine could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channels. It could also present as the hydro...

CAS 1841-19-6 Fluspirilene

Fluspirilene
(CAS: 1841-19-6)

Fluspirilene, with antipsychotic activity, is a non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 µM). Fluspirilene is also a...

CAS 167221-71-8 Clevidipine Butyrate

Clevidipine Butyrate
(CAS: 167221-71-8)

Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.

Etripamil
(CAS: 1593673-23-4)

Etripamil, a benzoates derivative, has been found to be a calcium channel antagonist that could be used against hypertension and arrhythmic. It is currently und...

CAS 72509-76-3 Felodipine

Felodipine
(CAS: 72509-76-3)

Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. It can lower blood pressure by reducing peripheral vascular resistance via a highly ...

CAS 91599-74-5 Benidipine HCl

Benidipine HCl
(CAS: 91599-74-5)

Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.

CAS 100427-26-7 Lercanidipine

Lercanidipine
(CAS: 100427-26-7)

Lercanidipine hydrochloride, a dihydropyridine compound, is a third generation calcium channel antagonist which shows longer duration of action of the past two ...

CAS 89226-75-5 Manidipine 2HCl

Manidipine 2HCl
(CAS: 89226-75-5)

Manidipine 2HCl, a HCl salt form of Manidipine, is a calcium channel blocker with IC50 of 2.6 nM.

CAS 54527-84-3 Nicardipine Hydrochloride

Nicardipine Hydrochloride
(CAS: 54527-84-3)

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.

CAS 63675-72-9 Nisoldipine

Nisoldipine
(CAS: 63675-72-9)

Nisoldipine is a calcium channel blocker, specific for L-type Cav1.2 with IC50 of 10 nM.

CAS 41332-24-5 NP-118809

NP-118809
(CAS: 41332-24-5)

NP-118809 is a N-type calcium channel blocker exhibits both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain...

CAS 108852-42-2 YS-201

YS-201
(CAS: 108852-42-2)

YS-201, also known as Diperdipine, is a dihydropyridine-type calcium channel antagonist potentially for the treatment of angina pectoris and hypertension.

CAS 99254-95-2 McN5691

McN5691
(CAS: 99254-95-2)

McN5691, an antihypertensive agent, is a voltage-sensitive calcium channel blocker.

CAS 75695-93-1 Isradipine

Isradipine
(CAS: 75695-93-1)

Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.

CAS 128229-52-7 TAMOLARIZINE

TAMOLARIZINE
(CAS: 128229-52-7)

Tamolarizin is a calcium antagonist originated by Nippon Chemiphar. Tamolarizin can induce the increase of GABA in the cerebellum and medulla oblongata followin...

CAS 180090-15-7 CP-​060

CP-​060
(CAS: 180090-15-7)

CP-​060 is a novel type of Ca(2+) antagonist possessing both Ca(2+) overload inhibition, with antioxidant and cardioprotective activities.

CAS 77-67-8 Ethosuximide

Ethosuximide
(CAS: 77-67-8)

Ethosuximide is a Calcium channel antagonist originated by Pfizer. It can be used for the treatment of Absence epilepsy and absence seizures. It may be used by ...

CAS 14663-23-1 Dantrolene Sodium

Dantrolene Sodium
(CAS: 14663-23-1)

Dantrolene Sodium, an inhibitor of calcium channel proteins that markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac,...

Chemical Structure

CAS 54527-84-3 Nicardipine Hydrochloride

Quick Inquiry

Verification code

Featured Items