|Description||Nestorone is a steroidal progestin of the 19-norprogesterone group which is used as a hormonal contraceptive in several South American countries. It is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities. It has been used as a female contraceptive and may be useful as a male contraceptive too recently. It does not bind to the estrogen receptor either, but it has some affinity for the glucocorticoid recepto. It appears to act as an agonist, but it does not appear to produce any glucocorticoid side effects unless used at high doses. It has been shown to have neurogenic and neuroprotective activity. It holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration. It protected against hippocampus abnormalities and improved functional outcomes of EAE mice, which suggests its potential value. It lacks affinity for the androgen receptor, thus does not produce any androgenic or anabolic effects. It is being in Clinical stage 1.|
|Appearance||White to beige powder|
|Synonyms||ST 1435;17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate;Elcometrine;16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate;Segesterone acetate;[(8R,9S,10R,13S,14S,17R)-17-acetyl-13-methyl-16-methylidene-3-oxo-2,6,7,8,9,10,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate|
|Solubility||10 mM in DMSO|
|Application||Nestorone is used as a hormonal contraceptive in several South American countries. It has been used as a female contraceptive and may be useful as a male contraceptive too recently. It lacks affinity for the androgen receptor, thus does not produce any androgenic or anabolic effects.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Boiling Point||499.3±45.0 °C | Condition: Press: 760 Torr|
|Density||1.15±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||Being in Clinical stage 1. Several Chinese companies or research institutions are developing the product, such as China Medicine University, Xianju Zhejiang pharmaceutical and so on.|
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