Nequinate - CAS 13997-19-8
Category: APIs
Molecular Formula:
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Nequinate is a medication used for the treatment of coccidiosis, and it is only approved for veterinary use in some countries.
Related CAS:
1584701-10-9 (labelled)
7-Benzyloxy-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methyl ester
1.Eimeria stiedai in rabbits: the demonstration of responses to chemotherapy.
Joyner LP, Catchpole J, Berrett S. Res Vet Sci. 1983 Jan;34(1):64-7.
The activity of sulphaquinoxaline, robenidine, methyl benzoquate, clopidol and a mixture of methyl benzoquate and clopidol (Lerbek; Dow), was studied in rabbits infected with hepatic coccidiosis due to Eimeria stiedai. Growth inhibition, oocyst production and the activity in the serum of glutamate dehydrogenase and gamma glutamyltransferase were studied as indicators of parasite development. Only sulphaquinoxaline and Lerbek gave satisfactory control of this parasite. The latter formulation was more effective than either of its constituents used alone.
2.Sensitivity of field isolates of Eimeria tenella to anticoccidial drugs in the chicken.
Chapman HD1. Res Vet Sci. 1989 Jul;47(1):125-8.
Thirty isolates of Eimeria tenella obtained from broiler and breeder farms were examined for their sensitivity to anticoccidial drugs. All were sensitive to robenidine, 28 were sensitive to methyl benzoquate, 25 to clopidol and 21 to nicarbazin. Most isolates were resistant or partly resistant to amprolium and dinitolmide.
3.Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials.
Daugschies A1, Gässlein U, Rommel M. Vet Parasitol. 1998 Apr 15;76(3):163-71.
Coccidia were isolated from a commercial broiler farm with a history of suspected drug resistance. The sensitivity profiles of the Eimeria spp. isolates against the anticoccidial drugs nicarbazin (NIC), narasin (NAR), halofuginone (HAL), salinomycin (SAL), meticlorpindol plus methylbenzoquate (MET), and monensin (MON) at the recommended dose levels were followed in three battery trials (B1, B2, B3) corresponding to a field study over three periods of commercial broiler keeping (F1, F2, F3). Shuttle programs were performed in F1 (NIC/MON) and in F2 (MET/MON) while only SAL was used in F3. Eimeria acervulina and E. tenella were isolated from indicator birds in F1 while only E. acervulina could be found during F2 and F3. In trial B1 the isolate from F1 was identified as resistant against HAL and partly resistant against NIC and MON, the two drugs that were used in F1. Following the replacement of NIC in the starter feed by MET the respective isolate from F2 showed no resistance against ionophores (trial B2) while partial resistance against HAL was still present.
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CAS 13997-19-8 Nequinate

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