Nepicastat HCl - CAS 170151-24-3
Catalog number:
B0084-453616
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H16ClF2N3S
Molecular Weight:
331.81
COA:
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Targets:
Dopamine β-hydroxylase
Description:
Nepicastat hydrochloride (SYN117, RS-25560-197) is an inhibitor of dopamine beta-hydroxylase that catalyzes the conversion of dopamine to norepinephrine. Nepicastat hydrochloride shows the selective and concentration-dependent inhibition effects on bovine and human dopamine-beta-hydroxylase activity in vitro. In vivo, Nepicastat hydrochloride increases dopamine content and dopamine/noradrenaline ratio in a dose-dependent manner. Nepicastat hydrochloride also produces the similar effects on noradrenaline, dopamine and dopamine/noradrenaline ratio in tissues and plasma of beagle dogs. Nepicastat is currently in Phase II clinical trials in patients with Posttraumatic Stress Disorder.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-453616 50 mg $198 In stock
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Brife Description:
inhibitor of dopamine beta-hydroxylase, Posttraumatic Stress Disorder
Purity:
>98%
Appearance:
solid powder
Synonyms:
N6022; Nepicastat hydrochloride; (S)-5-(aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione hydrochloride; Nepicastat (hydrochloride); UNII-3WK068D17I
MSDS:
Inquire
Application:
Nepicastat is currently in Phase II clinical trials in patients with Posttraumatic Stress Disorder.
Shelf Life:
2 years
InChIKey:
DIPDUAJWNBEVOY-PPHPATTJSA-N
InChI:
InChI=1S/C14H15F2N3S.ClH/c15-9-3-8-4-10(1-2-12(8)13(16)5-9)19-11(6-17)7-18-14(19)20;/h3,5,7,10H,1-2,4,6,17H2,(H,18,20);1H/t10-;/m0./s1
Canonical SMILES:
C1CC2=C(C=C(C=C2CC1N3C(=CNC3=S)CN)F)F.Cl
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