Nepafenac - CAS 78281-72-8
Catalog number:
78281-72-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H14N2O2
Molecular Weight:
254.28
COA:
Inquire
Targets:
Cox-2 | COX
Description:
An inhibitor of COX-1 and COX-2
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Brife Description:
An inhibitor of COX-1 and COX-2
Appearance:
Light Yellow Solid
Synonyms:
AHR 9434, AL 6515; 2-(2-amino-3-benzoylphenyl)acetamide
Solubility:
DMSO 50 mg/mL (196.63 mM); Water <1 mg/mL (<1 mM)
Storage:
3 years -20°C powder;6 months-80°C in solvent
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Melting Point:
177-181°C
InChIKey:
QEFAQIPZVLVERP-UHFFFAOYSA-N
InChI:
1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
Canonical SMILES:
C1=CC=C(C=C1)C(=O)C2=C(C(=CC=C2)CC(=O)N)N
1.Comparison of effect of nepafenac and diclofenac ophthalmic solutions on cornea, tear film, and ocular surface after cataract surgery: the results of a randomized trial.
Kawahara A1, Utsunomiya T2, Kato Y3, Takayanagi Y4. Clin Ophthalmol. 2016 Mar 4;10:385-91. doi: 10.2147/OPTH.S101836. eCollection 2016.
BACKGROUND: The aim of this study was to compare the effects of nepafenac ophthalmic suspension 0.1% (Nevanac) and diclofenac sodium ophthalmic solution 0.1% (Diclod) on the cornea, tear film, and ocular surface after cataract surgery.
2.One-Day Use of Preoperative Topical Nonsteroidal Anti-Inflammatory Drug Prevents Intraoperative Prostaglandin Level Elevation During Femtosecond Laser-Assisted Cataract Surgery.
Kiss HJ1, Takacs AI1, Kranitz K1, Sandor GL1, Toth G1, Gilanyi B2, Nagy ZZ1. Curr Eye Res. 2015 Dec 17:1-4. [Epub ahead of print]
PURPOSE: To determine if pretreatment with topical nonsteroidal anti-inflammatory drug (NSAID) prior to femtosecond laser-assisted cataract surgery (FLACS) prevents intraoperative prostaglandin level elevation as a potential risk factor of postoperative complications.
3.Prostaglandin E2 Levels of Aqueous and Vitreous Humor in Ketorolac 0.4% and Nepafenac 0.1% Administered Healthy Rabbits.
Acar U1, Acar DE2, Tanriverdi C3, Acar M4, Ozdemir O2, Erikci A5, Ornek F6. Ocul Immunol Inflamm. 2016 Jan 14:1-5. [Epub ahead of print]
PURPOSE: To compare the lowering effects of ketorolac 0.4% and nepafenac 0.1% on aqueous and vitreous humor prostaglandin E2 (PGE2) levels in rabbits.
4.Effect of topical ketorolac 0.4%, nepafenac 0.1%, and bromfenac 0.09% on postoperative inflammation using laser flare photometry in patients having phacoemulsification.
Sahu S1, Ram J2, Bansal R1, Pandav SS1, Gupta A1. J Cataract Refract Surg. 2015 Oct;41(10):2043-8. doi: 10.1016/j.jcrs.2015.10.061.
PURPOSE: To study the effect of topical ketorolac 0.4% (Acular LS), bromfenac 0.09% (Megabrom), and nepafenac 0.1% (Nevanac) on postoperative inflammation using laser flare photometry in patients having phacoemulsification with posterior chamber intraocular lens (PC IOL) implantation.
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CAS 78281-72-8 Nepafenac

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